Anti-Human Complement Factor B (BB Fragment) Antibody, clone 10-09
Mouse Anti-Human Monoclonal Antibody
|Application ||WB, IHC-F, FC, E|
|Calculated MW||85533 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Human factor B|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement factor B, 126.96.36.199, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, BF, BFD|
|Target/Specificity||ABD11836 recognises the Bb fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change which enables complement factor D to cleave the N-terminal of complement factor B, the Ba subunit, leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Storage at 4℃ or at -20℃.|
|Precautions||Anti-Human Complement Factor B (BB Fragment) Antibody, clone 10-09 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Xu, Y. et al. (2001) Structural biology of the alternative pathway convertase.Immunol. Rev. 180:123-135. 2. Ponnuraj, K. et al. (2004) Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.Mol. Cell. 14:17-28.
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