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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human Complement Factor B (BB Fragment) Antibody, clone 10-09    

Anti-Human Complement Factor B (BB Fragment) Antibody, clone 10-09

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P00751
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 10-09
Calculated MW 85533 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Human factor B
Shelf Life 18 months from date of despatch.
Gene ID 629
Other Names Complement factor B,, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, BF, BFD
Target/Specificity ABD11836 recognises the Bb fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change which enables complement factor D to cleave the N-terminal of complement factor B, the Ba subunit, leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Storage at 4℃ or at -20℃.
PrecautionsAnti-Human Complement Factor B (BB Fragment) Antibody, clone 10-09 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Xu, Y. et al. (2001) Structural biology of the alternative pathway convertase.
Immunol. Rev. 180:123-135. 2. Ponnuraj, K. et al. (2004) Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Mol. Cell. 14:17-28.

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Cat# ABD11836
(40 western blots)
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