|Application ||WB, IHC-F, FC, E|
|Calculated MW||139096 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A.|
|Immunogen||Purified human complement factor H from serum.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement factor H, H factor 1, CFH, HF, HF1, HF2|
|Target/Specificity||ABD11837 recognises human complement factor H which exists in 2 forms. The most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop.Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Complement Factor H Antibody, clone 10-10 is for research use only and not for use in diagnostic or therapeutic procedures.|
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