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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human Complement Factor H Antibody, clone 10-10    

Anti-Human Complement Factor H Antibody, clone 10-10

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08603
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 10-10
Calculated MW 139096 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A.
Immunogen Purified human complement factor H from serum.
Shelf Life 18 months from date of despatch.
Gene ID 3075
Other Names Complement factor H, H factor 1, CFH, HF, HF1, HF2
Target/Specificity ABD11837 recognises human complement factor H which exists in 2 forms. The most common form, of 150 kDa, and the less common form of 43 kDa. Factor H is secreted by the liver into the blood serum. It is important in regulating the complement pathway, preventing unnecessary inflammation which can damage the host tissue. Complement factor H functions as a cofactor in the inactivation of C3b by factor I. It makes C3b susceptible to cleavage by factor I, resulting in iC3b. Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase). This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop.Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Complement Factor H Antibody, clone 10-10 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Alexander, J. et al. (2007) The simple design of complement factor H: Looks can be deceiving.
Mol Immunol. 44: 123-132. 2. Harrison, R. et al. (1980) The physiological breakdown of the third component of human complement.
Mol. Immunol. 17: 9-20.

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Cat# ABD11837
(40 western blots)
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