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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human Complement Factor I Antibody, clone 3R/8    

Anti-Human Complement Factor I Antibody, clone 3R/8

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-F, E, Func
Primary Accession P05156
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 3R/8
Calculated MW 65750 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Native human factor I from serum.
Shelf Life 18 months from date of despatch.
Gene ID 3426
Other Names Complement factor I,, C3B/C4B inactivator, Complement factor I heavy chain, Complement factor I light chain, CFI, IF
Target/Specificity Mouse anti-Human Complement Factor I antibody, clone 3R/8 recognizes complement factor I, a member of the peptidase S1 family present in the blood plasma. Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors.Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome.Mouse anti-Human Complement Factor I antibody, clone 3R/8 blocks function of complement factor I.Removal of Sodium Azide is recommended prior to use in functional assays. AbD Serotec recommend the use of EQU003 for this purpose.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human Complement Factor I Antibody, clone 3R/8 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Dragon-Durey, M.V. et al. (2005) Atypical haemolytic uraemic syndrome and mutations in complement regulator genes.
Springer Semin Immunopathol. 27:359-374. 2. Nilsson, S. et al. (2007) A mutation in factor I that is associated with atypical hemolytic uremic syndrome does not affect the function of factor I in complement regulation.
Mol. Immunol. 44:1835-1844.

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Cat# ABD11838
(40 western blots)
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