|Application ||IHC-F, E|
|Calculated MW||51276 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified Human factor P from human serum|
|Shelf Life||18 months from date of despatch.|
|Other Names||Properdin, Complement factor P, CFP, PFC|
|Target/Specificity||ABD11839 recognises human complement factor P, a 53 kDa glycosylated protein present in blood serum. Factor P binds to microbial surfaces and binds and stabilizes the complement component 3- and complement component 5-convertase enzyme complexes. C3b then acts as an opsonin or initiates the complement pathway again creating a positive feedback loop which acts only on the bacterial cell, leaving the host cells unharmed. Deficiency of factor P makes the host more susceptible to bacterial infections, particularly to Neisseria species and meningococcal infections.ABD11839 does not inhibit function of complement factor P.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Factor P Antibody, clone 10-24 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Hourcade, D. et al. (2006) 1. (2006). The role of properdin in the assembly of the alternative pathway C3 convertases of complement. J. Biol. Chem. 281:2128-2132. 2. Jelezarova, E. et al. (2000) Interaction of C3b2–IgG complexes with complement proteins properdin, factor B and factor H: implications for amplification.Biochem. J. 349:217–223.
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