|Application ||WB, IHC-P|
|Clone Names||F38 P7 H9|
|Calculated MW||64616 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Ovalbumin-conuugated synthetic peptide AHTNLRLFHH|
|Shelf Life||18 months from date of despatch.|
|Other Names||Bifunctional purine biosynthesis protein PURH, Phosphoribosylaminoimidazolecarboxamide formyltransferase, 18.104.22.168, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR transformylase, IMP cyclohydrolase, 22.214.171.124, ATIC, IMP synthase, Inosinicase, ATIC, PURH|
|Target/Specificity||Mouse anti-ATIC antibody, clone F38 P7 H9 specifically recognizes ATIC,a ribonucleotide transformylase (AICAR transformylase) and member of the purH family, which helps catalyze the final steps of the purine biosynthesis pathway. ATIC has been identified as an activator of AMP-activated protein kinase (AMPK), a known regulator of energy homeostasis, inhibitor of cell proliferation and inducer of apoptosis in cancerous cells of various origins, making ATIC a potential therapeutic agent for cancer. The anti-inflammatory and neuroprotective functions of ATIC, also have implications for its use in the treatment of Alzheimer's disease.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-ATIC Antibody, clone F38 P7 H9 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Rattan, R. et al. (2005) 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside inhibits cancer cell proliferation in vitroandin vivo via AMP-activated protein kinase. J. Biol. Chem. 280: 39582-39593.
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