|Application ||WB, E, Func|
|Calculated MW||93518 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human C7.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement component C7, C7|
|Target/Specificity||Mouse anti-Human C7 antibody, clone 030-126.96.36.199 recognises complement component 7 (C7), a 110 kDa glycoprotein present in the blood serum. The factor I domain of C7 binds the C terminus of the C5 alpha-chain, acting as a membrane anchor. This enables the assembly of the complement membrane attack complex (MAC) and consequent complement lytic activity. C7 deficiency is associated with increased susceptibility to recurrent infections, in particular by Neisseria meningitides.Mouse anti-Human C7 antibody, clone 030-188.8.131.52 does not recognie membrane bound complement membrane attack complex.Mouse anti-Human C7 antibody, clone 030-184.108.40.206 inhibits lysis of sensitised sheep erythrocytes.Removal of Sodium Azide is recommended prior to use in functional assays. AbD Serotec recommend the use of EQU003 for this purpose.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C7 Antibody, clone 030-220.127.116.11 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Langer, F. et al. (2013) Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase.Blood. 121 (12): 2324-35.1. Thai, C. et al. (2005) Complement components C5 and C7: recombinant factor I modules of C7 bind to the C345C domain of C5. J. Immunol. 174: 6227-32.2. Debard AL et al. (2005) FcgammaRIIIb and complement component C7 codeficiency in a patient with recurrence of fulminant meningococcal septic shock. Clin. Infect. Dis. 40: 1679-83.
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