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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human C8 Antibody, clone 056B-373    

Anti-Human C8 Antibody, clone 056B-373

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P07358
Other Accession P07357, P07360
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 056B-373
Calculated MW 67047 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Purified human C8
Shelf Life 18 months from date of despatch.
Gene ID 732
Other Names Complement component C8 beta chain, Complement component 8 subunit beta, C8B
Target/Specificity ABD11850 recognises complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human C8 Antibody, clone 056B-373 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Rosa, D. (2004) Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis - case report and literature review.
Braz. J. Infect. Dis. 8: 328-330. 2. Schreck, S. et al. (2000) Human complement protein C8 gamma.
Biochim. Biophys. Acta. 1482: 199-208.

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Cat# ABD11850
(40 western blots)
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