|Application ||WB, IHC-F, FC, E|
|Other Accession||P07357, P07360|
|Calculated MW||67047 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human C8|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement component C8 beta chain, Complement component 8 subunit beta, C8B|
|Target/Specificity||ABD11850 recognises complement component 8 (C8), a 151 kDa member of the complement C6/C7/C8/C9 family, present in blood serum. C8 is a terminal component of the complement system, part of both the complement membrane attack complex (MAC), and important to MAC assembly. C8 binds to the C5b-7 complex, anchored to the membrane, creating C5b-8. C5b-8 binds C9 and catalyses the polymerization of C9 molecules to form C5-b9 (MAC). C8 is thought to contain lipid binding sites, facilitating the insertion of MAC into the membrane.Defects in the alpha chain of C8 can result in complement C8 deficiency type I. Furthermore, C8 deficiencies can cause recurring bacterial infections, in particular from Neisseria meningitides.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C8 Antibody, clone 056B-373 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Rosa, D. (2004) Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis - case report and literature review.Braz. J. Infect. Dis. 8: 328-330. 2. Schreck, S. et al. (2000) Human complement protein C8 gamma. Biochim. Biophys. Acta. 1482: 199-208.
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