|Calculated MW||63173 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human C9|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement component C9, Complement component C9a, Complement component C9b, C9|
|Target/Specificity||ABD11851 recognises complement component 9 (C9), a 71kDa member of the complement C6/C7/C8/C9 family present in the blood serum and synthesised by the liver and monocytes. C9 is the last component to be added during the formation of the membrane attack complex (MAC), binding the membrane associated C5b-8 complex and resulting in the circular polymerisation of 12-18 C9 molecules. This forms the hydrophilic transmembrane channel which causes cell lysis. Deficiency of C9 is associated with recurring infections by Neisseria meningitides.ABD11851 does not recognise MAC.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C9 Antibody, clone 002-94.8.8 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Huang, Y. et al. (2006) Defining the CD59-C9 binding interaction. J. Biol. Chem. 281:27398-27404.
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