Anti-Human Complement Factor B (Ba Fragment) Antibody, clone 014III-220.127.116.11
Mouse Anti-Human Monoclonal Antibody
|Application ||WB, IHC-F, FC, E, Func|
|Calculated MW||85533 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human complement factor b.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement factor B, 18.104.22.168, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, Complement factor B Ba fragment, Complement factor B Bb fragment, CFB, BF, BFD|
|Target/Specificity||Mouse anti-Human Complement Factor B (Ba Fragment) antibody, clone 014III-22.214.171.124 recognises the 30kDa Ba fragment of 90kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit), leaving the 63 kDa Bb subunit associated with C3b, forming C3 convertase. Subunit Ba inhibits lymphocyte proliferation. Conversely, subunit Bb is involved in the proliferation of preactivated B lymphocytes.Mouse anti-Human Complement Factor B (Ba Fragment) antibody, clone 014III-126.96.36.199 has been reported for use in functional studies to block activity of the target protein. Removal of Sodium Azide is recommended prior to use in functional assays. AbD Serotec recommend the use of EQU003 for this purpose.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Complement Factor B (Ba Fragment) Antibody, clone 014III-188.8.131.52 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Xu, Y. et al. (2001) Structural biology of the alternative pathway convertase.Immunol. Rev. 180:123-135. 2. Ponnuraj, K. et al. (2004) Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.Mol. Cell. 14:17-28.
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