|Application ||IHC-F, FC, E|
|Calculated MW||192751 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human C4d|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement C4-B, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Complement C4 beta chain, Complement C4-B alpha chain, C4a anaphylatoxin, C4b-B, C4d-B, Complement C4 gamma chain, C4B, CO4, CPAMD3|
|Target/Specificity||ABD11854 recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C4d (Neoantigen) Antibody, clone 057-188.8.131.52 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
1. Rogers, J. et al. (1992) Complement Activation by beta-amyloid in Alzheimer disease.PNAS 89: 10016-10020.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.