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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Human C4d (Neoantigen) Antibody, clone 057-    

Anti-Human C4d (Neoantigen) Antibody, clone 057-

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P0C0L5
Other Accession P0C0L4
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 057-
Calculated MW 192751 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein A
Immunogen Purified human C4d
Shelf Life 18 months from date of despatch.
Gene ID 100293534;721
Other Names Complement C4-B, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Complement C4 beta chain, Complement C4-B alpha chain, C4a anaphylatoxin, C4b-B, C4d-B, Complement C4 gamma chain, C4B, CO4, CPAMD3
Target/Specificity ABD11854 recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human C4d (Neoantigen) Antibody, clone 057- is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Rogers, J. et al. (1992) Complement Activation by beta-amyloid in Alzheimer disease.
PNAS 89: 10016-10020.

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Cat# ABD11854
(40 western blots)
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