|Application ||IHC-F, FC, E|
|Calculated MW||192751 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human C4d|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement C4-B, Basic complement C4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3, Complement C4 beta chain, Complement C4-B alpha chain, C4a anaphylatoxin, C4b-B, C4d-B, Complement C4 gamma chain, C4B, CO4, CPAMD3|
|Target/Specificity||ABD11854 recognises a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b’s alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosous.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C4d (Neoantigen) Antibody, clone 057-22.214.171.124 is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. Rogers, J. et al. (1992) Complement Activation by beta-amyloid in Alzheimer disease.PNAS 89: 10016-10020.
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