|Application ||IHC-F, FC, E|
|Calculated MW||104786 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human C6|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement component C6, C6|
|Target/Specificity||ABD11858 recognises complement component 6 (C6), a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C-terminus of the C5b alpha-chain, anchoring the molecule to the membrane; they also binds complement component 7. This enables the formation of the C5b–7 precursor complex. C5b–7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.ABD11858 recognises MAC.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C6 Antibody, clone 056B-188.8.131.52 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. DiScipio, R. et al. (1999) Function of the Factor I modules (FIMS) of human complement component C6. J. Biol. Chem. 274: 31811-31818.
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