|Application ||IHC-F, FC, E|
|Calculated MW||104786 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Purified human C6|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement component C6, C6|
|Target/Specificity||ABD11858 recognises complement component 6 (C6), a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C-terminus of the C5b alpha-chain, anchoring the molecule to the membrane; they also binds complement component 7. This enables the formation of the C5b–7 precursor complex. C5b–7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.ABD11858 recognises MAC.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C6 Antibody, clone 056B-22.214.171.124 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. DiScipio, R. et al. (1999) Function of the Factor I modules (FIMS) of human complement component C6. J. Biol. Chem. 274: 31811-31818.
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