|Application ||WB, E|
|Calculated MW||14296 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Human Urotensin II|
|Shelf Life||18 months from date of despatch.|
|Other Names||Urotensin-2, Urotensin II, U-II, UII, UTS2|
|Target/Specificity||Mouse anti-Human Urotensin II antibody, clone UII-9 detects Urotensin II (U-II), a cyclic heptapeptide that functions both as a potent vasoconstrictor and a neurotransmitter/neuromodulator. U-II circulates in the plasma as a zymogen, and is activated by the urotensin converting enzyme. U-II is the endogenous ligand for the G-protein coupled receptor 14 (GPR14), recently renamed the UT receptor. Changes in the expression of U-II and its receptor have been associated with cardiovascular and renal diseases, including atherosclerosis, myocardial infarction, and diabetic nephropathy.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Urotensin II Antibody, clone UII-9 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Watanabe, T. et al. (2006) Human urotensin II as a link between hypertension and coronary artery disease. Hypertens. Res. 29: 375-387.2. Nothacker, H.P. and Clark, S. (2005) From heart to mind. The urotensin II system and its evolving neurophysiological role. FEBS J. 272: 5694-5702.3. Zhu, Y.C. et al. (2006) The role of urotensin II in cardiovascular and renal physiology and diseases. Br. J. Pharmacol. 148: 884-901.
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