|Calculated MW||31223 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A|
|Immunogen||Recombinant full-length mature human CD257 expressed in E. coli.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Tumor necrosis factor ligand superfamily member 13B, B lymphocyte stimulator, BLyS, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1, TALL-1, CD257, Tumor necrosis factor ligand superfamily member 13b, membrane form, Tumor necrosis factor ligand superfamily member 13b, soluble form, TNFSF13B, BAFF, BLYS, TALL1, TNFSF20, ZTNF4|
|Target/Specificity||Mouse anti-Human CD257 antibody, clone 2B recognises CD257, also known as BAFF/BLyS. CD257 is a 285 amino acid type II transmembrane protein and member of the tumor necrosis factor (TNF) superfamily of ligands, which acts as a B and T cell stimulator and plays a role in the development of autoimmune diseases such as systemic lupus erythematosus. CD257 is expressed by monocytes, macrophages, T cells and dendritic cells and acts through binding to CD267 (TACI), CD269 (BCMA) and CD268 (BAFFR) receptors, the latter interaction playing a critical role in the activation, survival, differentiation and proliferation of B cells. Mouse anti-Human CD257 antibody, clone 2B has not been cross-adsorbed and may react with homologous proteins from related species.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Storage at 4℃ or at -20℃.|
|Precautions||Anti-Human CD257 Antibody, clone 2B is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Bossen, C. & Schneider, P. (2006) BAFF, APRIL and their receptors: structure, function and signaling.Semin Immunol. 18 (5): 263-75.
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