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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human alpha B Crystallin Antibody, clone 2E8    

Anti-Human alpha B Crystallin Antibody, clone 2E8

Mouse Anti-Human Monoclonal Antibody

  • WB - Anti-Human alpha B Crystallin Antibody, clone 2E8  ABD11869
    Western blotting analysis of anti alpha b crystallin antibody using Mouse anti Human alpha b crystallin clone 2E8 Lane 1: Recombinant alpha a crystallinLane 2: Recombinant alpha b crystallin
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P02511
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 2E8
Calculated MW 20159 Da
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography on Protein G from ascites
Immunogen Recombinant human alpha B crystallin (amino acids 1-175) purified from E. coli.
Shelf Life 18 months from date of despatch.
Gene ID 1410
Other Names Alpha-crystallin B chain, Alpha(B)-crystallin, Heat shock protein beta-5, HspB5, Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2
Target/Specificity Mouse anti-Human alpha B crystallin, clone 2E8 recognizes the basic (b) form of alpha crystallin, alpha B crystallin, a 20kDa water-soluble major structural protein and member of the heat shock protein family, designated HSPB5, which acts as a molecular chaperone and is believed to play a role in the maintenance of ocular lens transparency/refractive index.Besides the involvement of both alpha A and alpha B crystallin in the prevention of protein precipitation and cataract formation in the eye, alpha crystallins have also been demonstrated in other tissues including the heart, brain, kidney, spleen and thymus. Studies have shown that a mutation in alpha B crystallin is responsible for desmin-related myopathy (DRM) and cataract (Pernget al..). Alpha B crystallin is also a major component of the astrocytic inclusions known as Rosenthal fibers (RFs), found in Alexander's disease (Iwakiet al.1989).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human alpha B Crystallin Antibody, clone 2E8 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. van Nierop, G.P. et al. (2015) Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins.
Mult Scler. pii: 1352458515588581. 1. Perng, M.D. et al. (1999) The cardiomyopathy and lens cataract mutation in alphaB-crystallin alters its protein structure, chaperone activity, and interaction with intermediate filaments in vitro.
J Biol Chem. 274 (47): 33235-43.

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Cat# ABD11869
(40 western blots)
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