|Application ||WB, IHC-F, E|
|Calculated MW||49861 Da|
|Purification||Purified IgM prepared by ion exchange chromatography|
|Immunogen||Tubulin beta from porcine brain.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Tubulin beta chain, Beta-tubulin, TBB|
|Target/Specificity||Mouse anti-Pig Tubulin beta antibody, clone TU-13 recognizes an epitope within the N-terminal region (NT) of tubulin beta, a ~50 kDa globular protein and major constituent of microtubules within the cytoskeleton, involved in meiosis, mitosis, intracellular transport and maintaining cell shape.The evolutionarily conserved heterodimer tubulin, made up of a tubulin alpha and beta chain, binds two molecules of GTP, one at a non-exchangeable site on the alpha chain and one at an exchangeable site on the beta chain. Only the beta chain possesses GTPase activity however, hydrolysing GTP to GDP, and influencing the stability of the dimer within the microtubule.Mouse anti-Pig Tubulin beta antibody, clone TU-13 partially inhibits microtubule assembly in vitro(Draber, P. et al.). Mouse anti-Pig Tubulin beta antibody, clone TU-13 has also been successfully employed for the demonstration of neuronal cells in mouse brain by immunohistochemistry on floating sections (Novákováet al.1997).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Pig Tubulin beta (N-Terminal) Antibody, clone TU-13 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Dráber, P. et al. (1990) Inhibition of microtubule assembly in vitro by anti-tubulin monoclonal antibodies.FEBS Lett. 262 (2): 209-11. 3. Bataveljić D et al. (2012) Changes in the astrocytic aquaporin-4 and inwardly rectifying potassium channel expression in the brain of the amyotrophic lateral sclerosis SOD1(G93A) rat model.Glia. 60 (12): 1991-2003.1. Krauhs, E. et al. (1981) Complete amino acid sequence of beta-tubulin from porcine brain.Proc Natl Acad Sci U S A. 78 (7): 4156-60.
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