|Calculated MW||56427 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||Epstein-Barr nuclear antigen 1, EBNA-1, EBV nuclear antigen 1, EBNA1|
|Target/Specificity||Mouse anti-Epstein-Barr Virus Nuclear Antigen antibody, clone E1-2.5 recognises the repetitive Gly-Ala region of EBV (Epstein-Barr Virus) nuclear antigen 1 (EBNA-1), a viral protein expressed consistently by EBV- associated malignancies.Epstein-Barr Virus, also known as HHV-4 or Human herpesvirus 4, is a member of the herpesvirus family and one of the most common infectious viruses known, being responsible for a wide range of illnesses from infectious mononucleosis to nasal-pharyngeal cancer. EBNA-1 is the only viral protein expressed during group 1 latency and mediates the replication and partitioning of the episome during host cell division, binding to a replication origin (oriP) within the viral genome. The Gly-Ala repeat recognized by Mouse anti-Epstein-Barr Virus Nuclear Antigen antibody, clone E1-2.5, inhibits the host’s CD8-restricted cytotoxic T-cell response to infected cells, by impairing antigen processing and MHC class I-restricted antigen presentation.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Epstein-Barr Virus Nuclear Antigen Antibody, clone E1-2.5 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Sim AC et al. (2013) Defining the expression hierarchy of latent T-cell epitopes in Epstein-Barr virus infection with TCR-like antibodies.Sci Rep. 3: 3232.1. Munz, C. (1999) Epstein-barr virus nuclear antigen 1: from immunologically invisible to a promising T cell target.J. Exp. Med. 10: 1301-1304.
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