|Application ||E, IRMA|
|Calculated MW||31674 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from ascites|
|Immunogen||Recombinant human IGFBP-3.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Insulin-like growth factor-binding protein 3, IBP-3, IGF-binding protein 3, IGFBP-3, IGFBP3, IBP3|
|Target/Specificity||Mouse anti-Human IGFBP-3 clone 83.8F9 recognizes IGFBP-3, a member of the superfamily of insulin-like growth factor binding proteins that hold a central position in IGF ligand-receptor interactions through influences on both the bioavailability and distribution of IGFs in the extracellular environment. IGFBP-3 is found in human serum and has two forms of approximate molecular mass 40 and 43 kDa.IGFBP-3 binds IGF-1 and IGF-2 with similar high affinity. In the blood stream, approximately 90 % of IGFBP-3 is found in a ternary complex of 140 kDa. This complex comprises an acid-labile subunit (a-subunit), IGFBP-3 (ß-subunit) and IGF-1 or IGF-2. This binding prolongs the metabolic half-life of IGF-1 in circulation and serves as a metabolic reservoir of IGF-1.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Igfbp-3 Antibody, clone 83.8F9 is for research use only and not for use in diagnostic or therapeutic procedures.|
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