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Anti-Caspase-8 (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • WB - Anti-Caspase-8 (C-Terminal) Antibody  ABD11880
    Western blot analysis of lysate from Jurkat human T-cell leukemia cells probed with Rabbit anti Human caspase-8 at 0.5(A), 1(B) and 2(C) ug/ml
  • ICC - Anti-Caspase-8 (C-Terminal) Antibody  ABD11880
    Immunocytochemical staining of Jurkat cells with Rabbit anti Human caspase-8
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14790
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 55391 Da
Additional Information
Other Species Rat,M
Purification Antisera to human caspase-8 (CT) were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.
Immunogen A 16 amino acid peptide located near the carboxy-terminus of human caspase-8 isoform A.
Shelf Life 18 months from date of despatch.
Gene ID 841
Other Names Caspase-8, CASP-8,, Apoptotic cysteine protease, Apoptotic protease Mch-5, CAP4, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MORT1-associated ced-3 homolog, MACH, Caspase-8 subunit p18, Caspase-8 subunit p10, CASP8, MCH5
Target/Specificity ABD11880 recognises an epitope within the c-terminal region (CT) of caspase-8, otherwise known as Fas-linked ICE-like protease (FLICE), which shares homology with both Fas-associated via death domain (FADD) and the ICE/Ced-3 family of cysteine proteases.Caspase-8 is classified as an initiator caspase and acts as the most upstream trigger of Fas-Receptor (CD95) and tumour necrosis factor receptor 1 (TNFR1) mediated apoptosis. Upon activation, the cell death receptor Fas, links with the adaptor molecule FADD via corresponding death domains (DD). FADD in turn then binds via death effector domains (DEDs) to procaspase-8, which then undergoes oligomerization and autocatalytic activation.Active Caspase-8 is capable of cleaving all other known caspases, and also cleaves the Bcl-2 family member BH3-interacting domain death agonist (BID), along with the Bcl-2 associated protein p28Bap31, see Wolf, B. B. & Green, D. R. for details.
Preservative & Stabilisers 0.02% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Caspase-8 (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Muzio, M. et al. (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex.
Cell 85: 817 - 827.2. Wolf, B. B. and Green, D. R. (1999) Suicidal tendencies: apoptotic cell death by caspase family proteinases.
J. Biol. Chem. 274: 20049 - 20052.3. Cohen, G. M. (1997) Caspases: the executioners of apoptosis.
Biochem. J. 326: 1 - 16.

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Cat# ABD11880
(40 western blots)
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