|Calculated MW||37822 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Native, from placenta|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Cathepsin B, 220.127.116.11, APP secretase, APPS, Cathepsin B1, Cathepsin B light chain, Cathepsin B heavy chain, CTSB, CPSB|
|Target/Specificity||Sheep anti-Human cathepsin B antibody detects cathepsin B, a lysosomal cysteine protease which functions as both a endopeptidase and a carboxypeptidase. Together with cathepsins D and L, cathepsin B is one of the most abundant proteases in the lysosome, and participates in intracellular protein degradation.Cathepsin B is thought to play an increasingly important role in apoptosis and its release from the lysosome under cell stress leads to Bid cleavage, cytochrome C release and nuclear fragmentation.Cathepsin B is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete processing of APP is thought to be a causative factor in Alzheimer disease.Over-expression of cathepsin B has been associated with oesophageal adenocarcinoma and other tumours, and has in particular been implicated in tumour invasion and metastasis.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||Anti-Human Cathepsin B Antibody (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
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