|Application ||IHC-F, E|
|Calculated MW||122205 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Highly pure human ceruloplasmin|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Ceruloplasmin, 184.108.40.206, Ferroxidase, CP|
|Target/Specificity||Sheep anti-Human ceruloplasmin antibody detects ceruloplasmin, a ~132kDa metalloprotein that is secreted into the plasma by liver hepatocytes and activated monocytes/macrophages. Ceruloplasmin functions in copper transport, iron homeostasis, antioxidant defence, angiogenesis and coagulation.Deficiency in ceruloplasmin is termed aceruloplasminemia, an autosomal recessive disorder which leads to iron accumulation and tissue damage, in particular in the brain and visceral organs. Clinical features include retinal degeneration, diabetes mellitus and neurological disturbances.Elevated plasma ceruloplasmin has been shown to pose an increased risk in atherosclerosis and myocardial infarction.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Ceruloplasmin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Balmaña M (2015) Identification of potential pancreatic cancer serum markers: Increased sialyl-Lewis X on ceruloplasmin.Clin Chim Acta. pii: S0009-8981(15)00021-2. 1. Mazumder, B. et al. (2005) Regulation of macrophage ceruloplasmin gene expression: one paradigm of 3'-UTR-mediated translational control. Mol. Cells. 20: 167-172.
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