|Calculated MW||90569 Da|
|Purification||Antisera to human plasminogen were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Native, highly purified.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Plasminogen, 188.8.131.52, Plasmin heavy chain A, Activation peptide, Angiostatin, Plasmin heavy chain A, short form, Plasmin light chain B, PLG|
|Target/Specificity||Sheep anti-Human plasminogen antibody recognizes human plasminogen, a ~90 kDa single-chain glycoprotein and inactive precursor (zymogen) of plasmin, secreted by the liver and present in the blood and majority of extravascular body fluids.Plasminogen is the central component in the fibrinolytic system, and is converted into active plasmin through cleavage by the endogenous activators urokinase (u-PA) and tissue plasminogen activator (t-PA), in the presence of fibrin. The level of plasminogen is maintained in the plasma at around 200mg/L, with an increase being associated with hypothyroidism, obesity and pregnancy, and deficiencies with many disorders including thrombosis, liver disease, sepsis and hyperthyroidism.Sheep anti-Human plasminogen antibody has not been cross adsorbed and may cross react with plasminogen from other species.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||Anti-Human Plasminogen Antibody (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Clinton, S.R. et al. (2010) Binding and activation of host plasminogen on the surface of Francisella tularensis.BMC Microbiol. 10:76. 2. Samson, A.L. et al. (2009) A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury.Blood. 114: 1937-46. 3. Samson, A.L. et al. (2008) Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function.J Neurochem. 107: 1091-101. 4. Singh, B. et al.(2015)Moraxella catarrhalis binds plasminogen to evade host innate immunity.Infect Immun. pii: IAI.00310-15. 5. Borg, R.J. et al. (2015) Dendritic Cell-Mediated Phagocytosis but Not Immune Activation Is Enhanced by Plasmin.PLoS One. 10 (7): e0131216.4. Fears, R. (1989) Binding of plasminogen activators to fibrin: characterization and pharmacological consequences. Biochem. J. 261: 313-324.
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