|Application ||WB, E, Func|
|Calculated MW||15834 Da|
|Purification||Antisera to mouse IL-4 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography.|
|Immunogen||Recombinant mouse IL-4|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Interleukin-4, IL-4, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1, BSF-1, IGG1 induction factor, Lymphocyte stimulatory factor 1, Il4, Il-4|
|Target/Specificity||Rabbit anti-Mouse Interleukin-4 antibody recognizes mouse interleukin-4 (IL-4), also known as B-cell stimulatory factor 1, a 120 amino acid pleiotropic cytokine cleaved from a 140 amino acid precursor which interacts with multiple cell lineages, including T cells, fibroblasts and macrophages (Crawfordet al.1987).Interleukin-4 is one of the most important factors involved in B cell IgG1 and IgE class switching (Winteret al.1987). IL-4 acts as a regulator of low affinity Fc receptor for IgE (CD23) expression on both lymphocytes and monocytes (Miyajimaet al.1991,Hudaket al.1987). IL-4 acts through binding to it's cognate receptor CD124, a receptor which also binds the related cytokine IL-13.Interleukin -4 plays an important role in the alternative activation of murine macrophages as indicated by the ability to potently up-regulate the expression and activity of CD206, the macrophage mannose receptor (Steinet al.1992).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Mouse Interleukin-4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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1. de Barros, V.E.D. et al. (2011) An Experimental Model of Meningoencephalomyelitis by Rocio Flavivirus in Balb/C Mice: Inflammatory Response, Cytokine Production, and Histopathology Am J Trop Med Hyg. 85: 363-73. 2. Kim, S.R. et al. (2013) Endoplasmic reticulum stress influences bronchial asthma pathogenesis by modulating nuclear factor ?B activation.J Allergy Clin Immunol. pii: S0091-6749(13)01382-1.
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