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>   home   >   Products   >   Primary Antibodies   >   Metabolism   >   Anti-Rat Interleukin-1 beta Antibody    

Anti-Rat Interleukin-1 beta Antibody (Biotin)

Rabbit Anti-Rat Polyclonal Antibody

  • IHC - Anti-Rat Interleukin-1 beta Antibody (Biotin) ABD11927
    Published customer image:Rabbit anti Rat Interleukin-1β antibody used for the detection of IL-1β expressing neurons in rat brain by immnofluorescence and immunohistochemistry on formalin fixed, paraffin embedded sections.Image caption:Neuronal expression of IL-1β in the right hemisphere exposed to lipopolysaccharide (LPS) + hypoxia-ischemia (HI). Mean ± standard error of the mean (SEM) (pg/mg) of IL-1β (A) and TNF-α (B). Titrations were done by ELISA on total protein extracts from the right cerebral hemisphere exposed to LPS plus HI for 4 h to 24 h compared to control (Ctl). (C) Immunofluorescent staining of neuronal nuclei (NeuN) + IL-1β + cells in the fronto-parietal neocortex (D). Mean ± SEM (%) of neural cells expressing Il-1β. (E) Immunohistochemical staining of IL-1β expression on neurons (arrows) from fronto-parietal neocortex and caudate putamen at 4 h post-LPS + HI compared to Ctl. Scale bar = 50 µm (4 to 6 pups per experimental condition). Analysis of variance with Newman-Keuls post-test; *P = 0.05, **P = 0.01. h hour, F-P Fronto-parietal, WM White matter, CPu Caudate putamen, Iba1 Ionized calcium-binding adapter molecule 1, GFAP Glial fibrillary acidic protein.From: Savard A, Lavoie K, Brochu ME, Grbic D, Lepage M, Gris D, Sebire G. Involvement of neuronal IL-1β in acquired brain lesions in a rat model of neonatal encephalopathy. J Neuroinflammation. 2013 Sep 5;10:110.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q63264
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 30644 Da
Additional Information
Purification Antisera to rat IL-1 beta were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by antigen affinity chromatography.
Immunogen Recombinant rat IL-1 beta (PRP23)
Shelf Life 12 months from date of reconstitution.
Other Names Interleukin-1 beta, IL-1 beta, Il1b
Target/Specificity Rabbit anti-Rat Interleukin-1 beta antibody recognizes rat IL-1 beta.
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Rat Interleukin-1 beta Antibody (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Girard, S. (2008) Pro-inflammatory disequilibrium of the IL-1 beta/IL-1ra ratio in an experimental model of perinatal brain damages induced by lipopolysaccharide and hypoxia-ischemia.
Cytokine. 43: 54-62. 2. Glatz, T. et al. (2010) Peroxisome-proliferator-activated receptors gamma and peroxisome-proliferator-activated receptors beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain.
J Hypertens. 28: 1488-97. 3. Mahmood, J. et al. (2011) Mitigation of radiation-induced lung injury by genistein and EUK-207.
Int J Radiat Biol. 87: 889-901. 4. Weksler-Zangen, S. et al. (2008) Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat.
Diabetes. 57: 279-87. 5. Mahmood, J. et al. (2013) Mitigation of radiation-induced lung injury with EUK-207 and genistein: effects in adolescent rats.
Radiat Res. 179 (2): 125-34. 6. Cho, G.S. et al. (2013) N-methyl-D-aspartate receptor antagonists memantine and MK-801 attenuate the cerebral infarct accelerated by intracorpus callosum injection of lipopolysaccharides.
Neurosci Lett. pii: S0304-3940(13)00063-3. 7. Savard, A. et al. (2013) Involvement of neuronal IL-1β in acquired brain lesions in a rat model of neonatal encephalopathy.
J Neuroinflammation. 10: 110. 8. Aharon-Hananel G et al. (2015) Antidiabetic Effect of Interleukin-1β Antibody Therapy Through β-Cell Protection in the Cohen Diabetes-Sensitive Rat.
Diabetes. 64 (5): 1780-5.

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Cat# ABD11927
(40 western blots)
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