|Application ||FC, E, ID|
|Other Accession||P02746, P02747|
|Calculated MW||26017 Da|
|Purification||Antisera to human C1q were raised by repeated immunisation of sheep with highly purified antigen. Purified IgG was prepared from whole serum by ion exchange chromatography.|
|Immunogen||Human C1q, purified from plasma.|
|Shelf Life||18 months from the date of despatch.|
|Other Names||Complement C1q subcomponent subunit A, C1QA|
|Target/Specificity||Sheep anti-Human C1q antibody recognizes human C1q, a sub-component of the C1 complement component.|
|Preservative & Stabilisers||0.09% Sodium Azide; 0.1% EACA; 0.01% Benzamidine; 1mM EDTA0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human C1q Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hwang, H.Y. et al. (2008) Highly specific inhibition of C1q globular-head binding to human IgG: a novel approach to control and regulate the classical complement pathway using an engineered single chain antibody variable fragment.Mol Immunol. 45: 2570-80. 2. Cragg, M.S. and Glennie, M.J. (2004) Antibody specificity controls in vivo effector mechanisms of anti-CD20 reagents.Blood. 103: 2738-43. 3. Sárvári, M. et al. (2003) Inhibition of C1q-beta-amyloid binding protects hippocampal cells against complement mediated toxicity.J Neuroimmunol. 137: 12-8. 4. Lewis, M.J. et al. (2008) The different effector function capabilities of the seven equine IgG subclasses have implications for vaccine strategies.Mol Immunol. 45: 818-27. 5. Yuste, J. et al. (2007) Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae.PLoS Pathog. 3: 1208-19. 6. Tang, Z. et al. (2013) A human single-domain antibody elicits potent antitumor activity by targeting an epitope in mesothelin close to the cancer cell surface.Mol Cancer Ther. 12: 416-26. 7. John, M. et al. (2000) Nephrotic syndrome in a patient with IgA deficiency-associated mesangioproliferative glomerulonephritis.Pathology. 32 (1): 56-8.
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