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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-Human CD254 Antibody (Biotin)   

Anti-Human CD254 Antibody

Rabbit Anti-Human Polyclonal Antibody

     
  • IHC - Anti-Human CD254 Antibody  ABD11948
    Formalin fixed, paraffin embedded human metastatic carcinoma of breast lymph node, stained with Rabbit anti Human sRANKL following heat mediated antigen retrieval with sodium citrate buffer (pH6.0)
  • IHC-P - Anti-Human CD254 Antibody  ABD11948
    Formalin fixed, paraffin embedded human metastatic carcinoma of breast lymph node, stained with Rabbit anti Human sRANKL following heat mediated antigen retrieval with sodium citrate buffer (pH6.0)
  • IHC-P - Anti-Human CD254 Antibody  ABD11948
    Formalin fixed, paraffin embedded human metastatic carcinoma of breast lymph node, stained with Rabbit anti Human sRANKL following heat mediated antigen retrieval with sodium citrate buffer (pH6.0)
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O14788
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 35478 Da
Additional Information
Purification Antisera to human CD254 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Recombinant human CD254.
Shelf Life 12 months from date of reconstitution.
Gene ID 8600
Other Names Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, ODF, Osteoprotegerin ligand, OPGL, Receptor activator of nuclear factor kappa-B ligand, RANKL, TNF-related activation-induced cytokine, TRANCE, CD254, Tumor necrosis factor ligand superfamily member 11, membrane form, Tumor necrosis factor ligand superfamily member 11, soluble form, TNFSF11, OPGL, RANKL, TRANCE
Target/Specificity Rabbit anti-Human CD254 antibody recognizes the soluble form of human CD254, otherwise known as sRANKL, a ~20 kDa glycoprotein and member of the Tumour Necrosis Factor (TNF) superfamily, generated by proteolytic processing of the full-length CD254 membrane protein.CD254 is highly expressed by T lymphocytes and osteoblastic cells and plays a key role in the differentiation and activation of osteoclast precursors, acting as a ligand for both receptor activator of NF-KBeta (RANK) and the decoy receptor osteoprotegerin (OPG), which act as antagonists. Binding of CD254 to RANK is essential for the activation of osteoclastogenesis, stimulated by factors such as TNF-alpha, IL-1beta, IL-6 and IL-17, whereas binding to OPG neutralizes CD254, thereby inhibiting osteoclastogenesis.CD254 augments the dendritic cell (DC) stimulation of naïve T cell proliferation and may be involved in the regulation of DC-T cell interactions. CD254 is also involved in apoptosis, through activation of the antiapoptotic kinase AKT/PKB and the mTOR/S6K signalling pathway.
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Human CD254 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Boyle, W.J. et al. (2003) Osteoclast differentiation and activation.
Nature. 423 (6937): 337-42.

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Cat# ABD11948
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