Anti-Human Insulin-Like Growth Factor I Antibody
Rabbit Anti-Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application ![]()
| WB, IHC-P, E, Func |
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Primary Accession | P05019 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Polyclonal IgG |
Calculated MW | 21841 Da |
Purification | Antisera to human IGF-I were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography. |
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Immunogen | Recombinant human IGF-I |
Shelf Life | 12 months from date of reconstitution. |
Gene ID | 3479 |
Other Names | Insulin-like growth factor I, IGF-I, Mechano growth factor, MGF, Somatomedin-C, IGF1, IBP1 |
Target/Specificity | Rabbit anti-Human insulin-likegGrowth factor I antibody recognizes human IGF-I (Insulin-like Growth Factor I), a 70 amino acid secreted mitogenic polypeptide and member of the insulin gene family, produced primarily by the liver. IGF-I exhibits both autocrine and paracrine properties and has a widespread effect on cells including those of the bone, cartilage, muscle, nerves, skin, liver and lungs, playing a key role in cell proliferation and growth, inhibition of apoptosis and linked with tumour cell growth.IGF-I signals through binding to the type 1 insulin-like growth factor receptor (IGF-1R) and also to the insulin receptor (IR), resulting in the activation of the AKT signalling pathway. Production of IGF-I is stimulated by growth hormone (GH) and can be hindered by GH insensitivity, deficiency in GH receptors or a malfunction in the post GH receptor signalling pathway. |
Preservative & Stabilisers | Preservative Free |
Storage | Prior to reconstitution store at +4℃. Following reconstitution store at -20℃. |
Precautions | Anti-Human Insulin-Like Growth Factor I Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |

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Provided below are standard protocols that you may find useful for product applications.
References
1. Singer, C.F. et al. (2004) Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: Free IGF-II is correlated with breast cancer size. Clin. Can. Res. 10: 4003-4009.

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