|Application ||WB, IHC-P, E|
|Calculated MW||18641 Da|
|Purification||Antiserum to human leptin was raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.|
|Immunogen||Recombinant human leptin(PHP198)|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Leptin, Obese protein, Obesity factor, LEP, OB, OBS|
|Target/Specificity||This product recognises human leptin, a 16KDa major adipose-derived hormone and member of the leptin family, which plays a key role in appetite control and the regulation of energy expenditure.Secreted leptin associates with proteins within the bloodstream and is transported to the brain, where it inhibits or up-regulates the activity of neuropeptides such as neuropeptide Y (NPY) and alpha-melanocyte-stimulating hormone respectively. Leptin is a recognised marker of obesity, with a correlation between circulating levels of leptin and body fat mass, and defects in leptin production result in severe obesity. Regulators of leptin expression include insulin, cortisol, cAMP and thiazolidinediones.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Leptin Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Paracchini, V. et al. (2005) Genetics of leptin and obesity: a HuGE review. Am. J. Epidemiol. 162: 101-114.
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