|Application ||WB, E|
|Calculated MW||17504 Da|
|Purification||Antisera to human IL-17 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared by antigen affinity chromatography|
|Immunogen||Recombinant human IL-17|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, IL17A, CTLA8, IL17|
|Target/Specificity||Rabbit anti-Human Interleukin-17 antibody recognizes human IL-17 (Interleukin-17/17A), a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217).IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Interleukin-17 Antibody (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
2. Parsonage, G. et al. (2008) Prolonged, granulocyte-macrophage colony-stimulating factor-dependent, neutrophilsurvival following rheumatoid synovial fibroblast activation by IL-17 and TNFalpha.Arthritis Res Ther. 10: R47.1. Gaffen, S.L. (2004) Biology of recently discovered cytokines; Interleukin-17 – a unique inflammatory cytokine with roles in bone biology and arthritis. Arth. Res. and Therapy. 6: 240-247.
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