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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Human Insulin-Like Growth Factor II Antibody (Biotin)   

Anti-Human Insulin-Like Growth Factor II Antibody

Rabbit Anti-Human Polyclonal Antibody

     
  • IHC - Anti-Human Insulin-Like Growth Factor II Antibody  ABD11984
    Staining of formalin fixed, paraffin embedded normal human placenta with Rabbit anti Human insulin-like growth factor II
  • IHC-P - Anti-Human Insulin-Like Growth Factor II Antibody  ABD11984
    Staining of formalin fixed, paraffin embedded normal human placenta with Rabbit anti Human insulin-like growth factor II
  • IHC-P - Anti-Human Insulin-Like Growth Factor II Antibody  ABD11984
    Staining of formalin fixed, paraffin embedded normal human placenta with Rabbit anti Human insulin-like growth factor II
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E, Func
Primary Accession P01344
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 20140 Da
Additional Information
Purification Antisera to human IGF-II were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Recombinant human IGF-II
Shelf Life 12 months from date of reconstitution.
Gene ID 3481
Other Names Insulin-like growth factor II, IGF-II, Somatomedin-A, T3M-11-derived growth factor, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2
Target/Specificity Rabbit anti-Human Insulin-Like Growth Factor II antibody recognizes human IGF-II (Insulin-like Growth Factor II), a 67 amino acid mitogenic polypeptide and member of the Insulin gene family, synthesized by various foetal tissues during prenatal development, under the influence of placental lactogen.IGF-II is a growth factor which exhibits both paracrine and autocrine properties and signals by binding to the type 1 and type 2 insulin-like growth factor receptors (type 1 IGFR and type 2 IGFR), and also to the insulin receptor (IR). The availability of IGF-II is dependent upon its attachment to, and release from, various IGF binding proteins (IGFBPs), a relationship which has been investigated in breast cancer research (Singeret al.2004).
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Human Insulin-Like Growth Factor II Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

1. Terasawa, H. et al. (1994) Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins.
EMBO J. 13: 5590-5597. 2. Singer, C.F. et al. (2004) Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size.
Clin. Can. Res. 10: 4003-4009.

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