|Application ||WB, E, Func|
|Calculated MW||20140 Da|
|Purification||Antisera to human IGF-II were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human IGF-II|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Insulin-like growth factor II, IGF-II, Somatomedin-A, T3M-11-derived growth factor, Insulin-like growth factor II, Insulin-like growth factor II Ala-25 Del, Preptin, IGF2|
|Target/Specificity||Rabbit anti-Human Insulin-Like Growth Factor II antibody recognizes human IGF-II (Insulin-like Growth Factor II), a 67 amino acid mitogenic polypeptide and member of the Insulin gene family, synthesized by various foetal tissues during prenatal development, under the influence of placental lactogen.IGF-II is a growth factor which exhibits both paracrine and autocrine properties and signals by binding to the type 1 and type 2 insulin-like growth factor receptors (type 1 IGFR and type 2 IGFR), and also to the insulin receptor (IR). The availability of IGF-II is dependent upon its attachment to, and release from, various IGF binding proteins (IGFBPs), a relationship which has been investigated in breast cancer research (Singeret al.2004).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Insulin-Like Growth Factor II Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Terasawa, H. et al. (1994) Solution structure of human insulin-like growth factor II; recognition sites for receptors and binding proteins. EMBO J. 13: 5590-5597. 2. Singer, C.F. et al. (2004) Insulin-like growth factor (IGF)-I and IGF-II serum concentrations in patients with benign and malignant breast lesions: free IGF-II is correlated with breast cancer size.Clin. Can. Res. 10: 4003-4009.
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