|Application ||WB, E, Func|
|Calculated MW||24874 Da|
|Purification||Antisera to human IL-12 were raised by repeated immunisations of goats with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human IL-12(PHP100)|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Interleukin-12 subunit alpha, IL-12A, Cytotoxic lymphocyte maturation factor 35 kDa subunit, CLMF p35, IL-12 subunit p35, NK cell stimulatory factor chain 1, NKSF1, IL12A, NKSF1|
|Target/Specificity||Rabbit anti-Human Interleukin-12 antibody, recognizes human IL-12. IL-12 is a pleiotropic 75kDa heterodimeric glycoprotein, consisting of disulfide-linked IL-12A (p35) and IL-12B (p40) subunits, which signals through the high affinity IL-12 receptor.IL-12 is produced primarily by antigen presenting cells and was originally called cytotoxic lymphocyte maturation factor (CLMF), identified by its ability to induce cytotoxic effector cells, in synergy with IL-2. IL-12 is an important factor in the T helper cell (Th1) immune response, promotes the development and activity of activated T cells and natural killer cells (NK), induces IFN-gamma production, and enhances resistance against invading pathogens.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human Interleukin-12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Munari, F. et al. (2014) Cytokine BAFF Released by Helicobacter pylori-Infected Macrophages Triggers the Th17 Response in Human Chronic Gastritis.J Immunol. pii: 1302865.1. Gubler, U. et al. (1991) Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. P.N.A.S. 88: 4143-4147.2. Rossol, S. et al. (1997) Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J. Clin. Invest. 99: 3025-3033.
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