|Application ||WB, IHC-P, E|
|Calculated MW||10881 Da|
|Purification||Antisera to human IP-10 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human IP-10.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-X-C motif chemokine 10, 10 kDa interferon gamma-induced protein, Gamma-IP10, IP-10, Small-inducible cytokine B10, CXCL10(1-73), CXCL10, INP10, SCYB10|
|Target/Specificity||Rabbit anti-Human IP-10 antibody recognizes human IP-10 (10-kDa interferon-inducible protein), otherwise known as CXCL10, a 77 amino acid CXC chemokine which, like monokine induced by IFN-gamma (Mig) and IFN-inducible T-cell alpha-chemoattractant (I-TAC), signals through the CXCR3 receptor.IP-10 acts as a chemoattractant for Th1 lymphocytes and natural killer (NK) cells and is secreted by a variety of cells, including neutrophils, monocytes, keratinocytes and epithelial cells, in response to interferon gamma (IFNgamma) and lipopolysaccharide (LPS). IP-10 is thus associated with several clinical conditions linked with Th1 type immune responses and raised IFNgamma expression, such as psoriasis, sarcoidosis and viral meningitis. In addition, studies have demonstrated the ability of IP-10 to suppress the synergistic action of stimulatory cytokines on hematopoietic progenitor cell proliferation.|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human IP-10 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Cox, M.A. et al. (2001) Human interferon-inducible 10-kDa protein and human interferon-inducible T cell alpha chemoattractant are allotopic ligands for human CXCR3: Differential binding to receptor states. Mol. Pharmacol. 59: 707-715.2. Sauty, A. et al. (1999) The T cell-specific CXC chemokines IP-10, Mig and I-TAC are expressed by activated human bronchial epithelial cells. J. Immunol. 162: 3549-3558.
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