|Application ||WB, E, Func|
|Calculated MW||10625 Da|
|Purification||Antisera to human MDC were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.|
|Immunogen||Recombinant human MDC.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||C-C motif chemokine 22, CC chemokine STCP-1, MDC(1-69), Macrophage-derived chemokine, Small-inducible cytokine A22, Stimulated T-cell chemotactic protein 1, MDC(3-69), MDC(5-69), MDC(7-69), CCL22, MDC, SCYA22|
|Target/Specificity||Rabbit anti-Human MDC antibody recognizes human MDC, also known as macrophage-derived cytokine, CCL22, CC chemokine STCP-1, Small-inducible cytokine A22 or Stimulated T-cell chemotactic protein 1. MDC is a 93 amino acid, ~10.6 kDa member of the CC chemokine family expressed by macrophages, monocyte-derived dendritic cells, epithelial cells, fibroblasts and highly expressed in the thymus. MDC acts as a chemoattractant for monocytes, dendritic cells, activated T lymphocytes and NK cells, through binding to chemokine (C-C motif) receptor 4 (CCR4). CCR4 is selectively expressed by Th2 cells and several studies have revealed a link between MDC and another ligand of CCR4, known as activation-regulated chemokine (TARC/CCL17), with Th2-mediated inflammatory disorders such as atopic dermatitis and ulcerative colitis (Judge et al.2001).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.|
|Precautions||Anti-Human MDC Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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2. Tsujikawa, T. et al. (2012) Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasis via CCR4/CCL22 in head and neck squamous cell carcinoma.Int J Cancer. Nov 26. [Epub ahead of print]1. Imai, T. et al. (1998) Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4*. J. Biol. Chem. 273: 1764-1768.
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