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Anti-Human Oncostatin M Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC - Anti-Human Oncostatin M Antibody  ABD11991
    Formalin fixed, paraffin embedded human breast malignant adenocarcinoma stained with Rabbit anti Human oncostatin M (AHP791 following enzyme mediated antigen retrieval using proteinase K
  • IHC-P - Anti-Human Oncostatin M Antibody  ABD11991
    Formalin fixed, paraffin embedded human breast malignant adenocarcinoma stained with Rabbit anti Human oncostatin M (AHP791 following enzyme mediated antigen retrieval using proteinase K
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Func
Primary Accession P13725
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 28484 Da
Additional Information
Purification Antisera to human Oncostatin M were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG prepared by affinity chromatography.
Immunogen Recombinant human Oncostatin M.
Shelf Life 12 months from date of reconstitution.
Gene ID 5008
Other Names Oncostatin-M, OSM, OSM
Target/Specificity Rabbit anti-Human Oncostatin M antibody recognizes human Oncostatin M (OSM), a 209 amino acid pleiotropic cytokine, originally isolated from PMA (phorbol 12-myristate 13-acetate) treated U937 leukaemia cells and mitogen-activated T lymphocytes.OSM was identified by the ability to inhibit the replication of various human tumour cell lines, but has also been shown to exert a stimulatory effect on fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, and to induce the release of certain cytokines by endothelial cells. OSM signals through binding with low affinity to the gp130 protein present in two cell surface receptors: type I consisting of gp130 and LIFR (leucocyte inhibitory factor receptor) which also acts as a receptor for LIF, and type II consisting of gp130 and OSMR, which mediates OSM specific activities.
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Human Oncostatin M Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Rose, T.M. and Bruce, A.G. (1991) Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.
P.N.A.S. 88: 8641-8645.2. Mosley, B. et al. (1996) Dual oncostatin M (OSM) receptors. Cloning and characterization of an alternative signaling subunit conferring OSM-specific receptor activation.
J. Biol. Chem. 271: 32635-32643.

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Cat# ABD11991
(40 western blots)
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