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>   home   >   Products   >   Primary Antibodies   >   Microbiology   >   Anti-Human Defensin beta 2 Antibody (Biotin)   

Anti-Human Defensin beta 2 Antibody

Goat Anti-Human Polyclonal Antibody

     
  • IHC - Anti-Human Defensin beta 2 Antibody  ABD11995
    Staining of formalin fixed, paraffin embedded inflamed oral mucosa with Goat anti Human beta defensin-1
  • IHC-P - Anti-Human Defensin beta 2 Antibody  ABD11995
    Staining of formalin fixed, paraffin embedded inflamed oral mucosa with Goat anti Human beta defensin-1
  • IHC-P - Anti-Human Defensin beta 2 Antibody  ABD11995
    Staining of formalin fixed, paraffin embedded inflamed oral mucosa with Goat anti Human beta defensin-1
  • IHC-P - Anti-Human Defensin beta 2 Antibody  ABD11995
    Staining of formalin fixed, paraffin embedded inflamed oral mucosa with Goat anti Human beta defensin-1
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E, Func
Primary Accession O15263
Reactivity Human
Host Goat
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 7038 Da
Additional Information
Purification Purified IgG was prepared by affinity chromatography.
Immunogen Recombinant human Defensin beta-2(PHP161).
Shelf Life 12 months from date of reconstitution.
Gene ID 100289462;1673
Other Names Beta-defensin 4A, Beta-defensin 2, BD-2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1, DEFB4A, DEFB102, DEFB2, DEFB4
Target/Specificity Goat anti-Human Defensin beta 2 polyclonal antibody recognizes human Defensin beta-2 (BD-2), a ~4.3kDa cationic antimicrobial peptide, also known as Beta-defensin 4A or Skin-antimicrobial peptide 1 (SAP-1) expressed primarily by epithelial cells of the respiratory tract and skin, and an important component of the innate immune response against microbial infections.Expression of BD-2 is induced during inflammation in response to bacterial products and cytokines, and is initially expressed in a precursor form, which is cleaved to release the C-Terminal active portion of the protein which is secreted by the neutrophil and binds to bacterial membranes causing their disruption.
Preservative & Stabilisers Preservative Free
Storage Prior to reconstitution store at +4℃. Following reconstitution store at -20℃.
PrecautionsAnti-Human Defensin beta 2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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References

3. Crack, L.R. et al. (2012) Human antimicrobial peptides LL-37 and human ß-defensin-2 reduce viral replication in keratinocytes infected with varicella zoster virus
Clin Exp Dermatol. 37: 534-43.1. Bals, R. et al. (1998) Human β-Defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.
J. Clin. Invest. 102: 874-880.2. Harder, J. et al. (2000) Mucoid Pseudomonas aeruginosa, TNF-α, and IL-1β, but not IL-6, induce human β-Defensin-2 in respiratory epithelia.
Am. J. Respir. Cell Mol. Biol. 22: 714-721.

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Cat# ABD11995
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