|Application ||FC, IP|
|Purification||Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti-Horse CD4 antibody, clone CVS4 recognizes Equine CD4, a ~58 kDa cell surface glycoprotein that is primarily expressed on a subpopulation of T lymphocytes. As in humans, equine CD4 expression is mutually exclusive with CD8 expression on mature T-cellsA study undertaken using Mouse anti-Horse CD4, clone CVS4 to identify CD4 on several wild african equid species indicates that the CVS4 clone recognizes Somali wild ass (Equus asinus) but not Grévy's Zebra (E. grevyi) or Hartmann's Mountain Zebra (E. zebra).In addition to the CVS4 clone, other CVS clones recognising equine cell surface and MHC antigen are available from AbD Serotec.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Horse CD4 Antibody, clone CVS4 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Lunn, D.P.et al. (1991) Three monoclonal antibodies identifying antigens on all equine T lymphocytes, and two mutually exclusive T-lymphocyte subsets.Immunol. 74: 251-257. 2. Kydd, J.H. and Antczak, D.F., (1991) Report of the First International Workshop on Equine Leucocyte Antigens, Cambridge, UK, July 1991Equine Immunol. 4-5. 3. Deeg,C.A. et al. (2004) The uveitogenic potential of retinal S-antigen in horses.Invest Ophthalmol Vis Sci. 45: 2286-92 4. Pearson, W. et al. (2007) Low-dose ginseng (Panax quinquefolium) modulates the course and magnitude of the antibody response to vaccination against equid herpesvirus I in horses. Can J Vet Res. 71: 213-7. 5. Brault, S.A. et al. (2010) The immune response of foals to natural infection with equid herpesvirus-2 and its association with febrile illness.Vet Immunol Immunopathol. 137: 136-41. 6. Goodman, L.B. et al. (2007) A point mutation in a herpesvirus polymerase determines neuropathogenicity.PLoS Pathog. 3(11):e160. 7. Hamza, E.et al. (2012) CD4+CD25+ T cells expressing FoxP3 in Icelandic horses affected with insect bite hypersensitivity.Vet Immunol Immunopathol. 148 (1-2): 139-44. 8. Go, Y.Y. et al. (2010) Complex interactions between the major and minor envelope proteins of equine arteritis virus determine its tropism for equine CD3+ T lymphocytes and CD14+ monocytes.J Virol. 84: 4898-911 9. Lunn, D.P. et al. (1998) Report of the Second Equine Leucocyte Antigen Workshop, Squaw valley, California, July 1995.Vet Immunol Immunopathol. 62: 101-143 10. Ibrahim, S. (2007) Analysis of monoclonal antibody cross-reactivity with leukocytes from equids and cloning of CD28.Anchor Text 11. Lai SW et al. (2004) Influence of Ganoderma lucidum on blood biochemistry and immunocompetence in horses.Am J Chin Med. 32 (6): 931-40. 12. Ferreira-Dias, G. et al. (2005) Seasonal reproduction in the mare: possible role of plasma leptin, body weight and immune status.Domest Anim Endocrinol. 29 (1): 203-13. 13. Agrícola, R. et al. (2008) Blood lymphocyte subpopulations, neutrophil phagocytosis and proteinogram during late pregnancy and postpartum in mares.Reprod Domest Anim. 43 (2): 212-7. 14. de Bruijn, C.M. et al. (2007) Clinical, histopathological and immunophenotypical findings in five horses with cutaneous malignant lymphoma.Res Vet Sci. 83 (1): 63-72. 15. Roberto Da Costa, R.P. et al. (2003) Peripheral blood neutrophil function and lymphocyte subpopulations in cycling mares.Reprod Domest Anim. 38 (6): 464-9. 16. Uner, A. G. et al. (2013) Blood Levels of Selected Metabolic Factors, Cytokines, and Lymphocyte Subpopulations in Arabian and Thoroughbred Horses During the Longest and Shortest Days of the YearJ Equine Vet Sci. 33 (11): 969-976. 17. Garcia-Tapia, D. et al. (2006) Replication of West Nile virus in equine peripheral blood mononuclear cells.Vet Immunol Immunopathol. 110 (3-4): 229-44. 18. Tessier, L. et al. (2015) Phenotypic and immunomodulatory properties of equine cord blood-derived mesenchymal stromal cells.PLoS One. 10 (4): e0122954. 19. Khol-Parisini, A. et al. (2012) Highly deoxynivalenol contaminated oats and immune function in horses.Arch Anim Nutr. 66 (2): 149-61.
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