|Application ||IHC-F, IF, FC|
|Calculated MW||27456 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatent.|
|Immunogen||Mouse spleen cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2|
|Target/Specificity||Rat anti-Mouse CD8, clone YTS105.18 recognizes a non polymorphic epitope on the mouse CD8 alpha chain. This antibody has been reported to block MHC I dependent T cell responses in vitroandin vivo, and induces transplantation tolerance in combination with CD4 antibodies (Cobboldet al.1990&Wiseet al.1998).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Mouse CD8 Antibody, clone YTS105.18 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Qin, S. et al. (1990) Induction of tolerance in peripheral T cells with monoclonal antibodies.Eur. J. Immunol. 20: 2737-2745. 2. Cobbold, S.P. et al. (1990) The induction of skin graft tolerance in MHC-mis matched or primed recipients: primed T-cells can be tolerized in the periphery with CD4 and CD8 antibodies.Eur. J. Immunol. 20: 2747-2755. 3. Wise, M.P. et al. (1998) Cutting edge: Linked suppression of skin graft rejection can operate through indirect recognition.J. Immunol. 161: 5813-5816. 4. Lacroix-Lamande, S. et al. (2009) Neonate intestinal immune response to CpG oligodeoxynucleotide stimulation.PLoS One. 4: 1-8. 5. Auray, G. et al. (2007) Involvement of intestinal epithelial cells in dendritic cell recruitment during C. parvum infection Microbes Infect. 9: 574-82. 6. Sroga, J.M. et al. (2003) Rats and mice exhibit distinct inflammatory reactions after spinal cord injury.J Comp Neurol. 462: 223-40. 7. Karlsson, M.R. et al. (2010) Hypersensitivity and oral tolerance in the absence of a secretory immune system.Allergy. 65: 561-70. 8. Himoudi, N. et al. (2007) Development of anti-PAX3 immune responses; a target for cancer immunotherapy Cancer Immunol Immunother. 56: 1381-95. 9. Nakashima, H. et al. (2011) A Novel Combination Immunotherapy for Cancer by IL-13Ra2-Targeted DNA Vaccine and Immunotoxin in Murine Tumor Models.J Immunol. 187: 4935-46.
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