|Calculated MW||130848 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Human CTL line directed against HLA-DR.|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, CD49a, ITGA1|
|Target/Specificity||Mouse anti-Human CD49a antibody, clone TS2/7 recognizes the human alpha 1 integrin sub-unit, which forms the VLA-1 heterodimer in association with the beta 1 integrin. VLA-1 is a receptor for collagen and laminin, and is expressed by chronically activated T cells, melanoma cells and smooth muscle cells.Mouse anti-Human CD49a antibody, clone TS2/7 has been reported as being suitable for use in Western Blotting.Mouse anti-Human CD49a antibody, clone TS2/7 is routinely tested in flow cytometry using HeLa cells.|
|Preservative & Stabilisers||0.09% Sodium Azide; 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD49a Antibody, clone TS2/7 (Biotin) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Hemler, M.E. et al. (1984) Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell linesJ. Immunol. 132: 3011. 2. Hemler, M. E. et al. (1985) Biochemical characterization of VLA-1 and VLA-2. Cell surface heterodimers on activated T cellsJ. Biol. Chem. 260: 15246-15252. 3. Hafler, D. A. et al. (1985) Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases.Clin. Immunol. Immunopathol. 37: 163-171. 4. Klemmt, P.A. et al. (2007) Endometrial cells from women with endometriosis have increased adhesion and proliferative capacity in response to extracellular matrix components: towards a mechanistic model for endometriosis progression.Hum Reprod. 22: 3139-47. 5. Berry, P.A. et al. (2011) The calcium sensor STIM1 is regulated by androgens in prostate stromal cells.Prostate. 71: 1646-55. 6. Elshaw, S.R. et al. (2001) A comparison of ocular melanocyte and uveal melanoma cell invasion and the implication of alpha1beta1, alpha4beta1 and alpha6beta1 integrins.Br J Ophthalmol. 85: 732-8. 7. Cervar-Zivkovic, M. et al. (2011) Endothelin-1 Stimulates Proliferation of First-Trimester Trophoblasts via the A- and B-Type Receptor and Invasion via the B-Type Receptor.J Clin Endocrinol Metab. 96: 3408-15. 8. Klemmt, P.A. et al. (2007) Endometrial cells from women with endometriosis have increased adhesion and proliferative capacity in response to extracellular matrix components: towards a mechanistic model for endometriosis progression.Hum Reprod. 22: 3139-47. 9. Kaneko, Y. et al. (2012) Integrin a1/ß1 and a2/ß1 as a receptor for IgA1 in human glomerular mesangial cells in IgA nephropathy.Int Immunol. 24: 219-32.
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