|Application ||IHC-F, FC, IP|
|Calculated MW||112916 Da|
|Purification||Purified IgG prepared by ion exchange chromotography|
|Immunogen||Human IM9 cell line.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor, EBV receptor, CD21, CR2, C3DR|
|Target/Specificity||Mouse anti-Human CD21 antibody, clone LB21 recognizes the human Complement receptor type 2, also known as CD21 or the Epstein-Barr virus receptor. CD21 is a ~14 kDa cell surface glycoprotein expressed by mature B cells and by follicular dendritic cells. The molecule acts as a receptor for complement components C3d, C3dg and iC3b, as well as for Epstein Barr Virus. It forms part of a large signal transduction complex in association with CD19.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD21 Antibody, clone LB21 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Furukawa, Y. et al. (2000) Frequent reversible membrane damage in peripheral blood B cells in human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP).Clin Exp Immunol. 120 (2): 307-16. 2. Griebel, P.J. et al. (2007) Cross-reactivity of mAbs to human CD antigens with sheep leukocytes.Vet Immunol Immunopathol. 119: 115-22. 3. Aasted, B. et al. (2007) Reactivity of monoclonal antibodies to human CD antigens with cells from mink.Vet Immunol Immunopathol. 119: 27-37. 4. Sopp, P. et al. (2007) Cross-reactivity of mAbs to human CD antigens with cells from cattle.Vet Immunol Immunopathol. 119: 106-14. 5. Davis, W.C. et al. (2007) Use of flow cytometry to identify monoclonal antibodies that recognize conserved epitopes on orthologous leukocyte differentiation antigens in goats, llamas, and rabbits.Vet Immunol Immunopathol. 119: 123-30. 6. Aichem, A. et al. (2006) Redox regulation of CD21 shedding involves signaling via PKC and indicates the formation of a juxtamembrane stalk.J Cell Sci. 119: 2892-902. 7. Angel, C.E. et al. (2009) Distinctive localization of antigen-presenting cells in human lymph nodes.Blood. 113: 1257-67. 8. Sengstake, S. et al. (2006) CD21 and CD62L shedding are both inducible via P2X7Rs.Int Immunol. 18: 1171-8. 9. Clutterbuck, E.A. et al. (2012) Pneumococcal conjugate and plain polysaccharide vaccines have divergent effects on antigen-specific B cells.J Infect Dis. 205: 1408-16. 10. Meister, R.K. et al. (2007) Progress in the discovery and definition of monoclonal antibodies for use in feline research.Vet Immunol Immunopathol. 119: 38-46. 11. Damgaard, B.M. et al. (2012) The effects of feed restriction on physical activity, body weight, physiology, haematology and immunology in female mink.Res Vet Sci. 93: 936-42. 12. Stachowiak, B. & Weingartl, H.M. (2012) Nipah virus infects specific subsets of porcine peripheral blood mononuclear cells.PLoS One. 7 (1): e30855.
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