|Application ||IHC-F, FC, IP|
|Calculated MW||25729 Da|
|Other Species||Marmoset,Chimpanzee,Cynomolgus Pr,Red-bellied Tamarin|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Normal human peripheral blood lymphocytes.|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, CD8a, CD8A, MAL|
|Target/Specificity||Mouse anti-Human CD8 antibody, clone LT8 recognizes the human CD8 cell surface glycoprotein expressed by a subset of peripheral blood T cells which express cytotoxic/suppressor activity. It is also expressed weakly on NK cells.The CD8 antigen is a co-receptor for MHC Class I in conjunction with the T cell receptor, and is important in the selection process of CD8+ MHC Class I restricted T cells.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD8 Antibody, clone LT8 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Zarkesh-Esfahani, H. et al. (2001) High-dose Leptin activates human leukocytes via receptor expression on monocytes. J. Immunol. 167: 4593 - 4599. 2. Manninen, A. et al. (2002) HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J. Exp.Med. 195 (8): 1023 -1032. 3. Parnes, J.R. (1989) Molecular biology and function of CD4 and CD8. Adv. Immunol. 44: 265-311. 4. Kap, Y.S. et al. (2009) A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates.J Histochem Cytochem. 57: 1159-67. 5. Hovden, A.O. et al. (2011) Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses.BMC Immunol. 12: 2. 6. Nelson, M. et al. (2010) Characterization of lethal inhalational infection with Francisella tularensis in the common marmoset (Callithrix jacchus).J Med Microbiol. 59: 1107-13. 7. Gibbings, D.J. et al. (2007) CD8 alpha is expressed by human monocytes and enhances Fc gamma R-dependent responses.BMC Immunol. 8: 12. 8. Junker, A. et al. (2007) Multiple sclerosis: T-cell receptor expression in distinct brain regions.Brain. 130: 2789-99. 9. Held, K. et al. (2011) Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates.J Virol. 85 (19): 9680-5. 10. Hood, S.P. et al. (2013) Changes in immune cell populations in the periphery and liver of GBV-B-infected and convalescent tamarins (Saguinus labiatus).Virus Res. pii: S0168-1702(13)00396-1. 11. Nelson, M. & Loveday, M. (2014) Exploring the innate immunological response of an alternative nonhuman primate model of infectious disease; the common marmoset.J Immunol Res. 2014: 913632.
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