|Application ||FC, IP|
|Calculated MW||19046 Da|
|Purification||Purified IgG prepared by ion exchange chromatography|
|Immunogen||Human red blood cells and platelets|
|Shelf Life||18 months from date of despatch.|
|Other Names||Platelet glycoprotein IX, GP-IX, GPIX, Glycoprotein 9, CD42a, GP9|
|Target/Specificity||Mouse anti-Human CD42a antibody, clone GRP-P recognizes the platelet GPIX glycoprotein, a 23kDa surface marker expressed by platelets and megakaryocytes. Platelet GPIX is also known as CD42a.The CD42 complex is the major platelet receptor for von Willebrand factor.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD42a Antibody, clone GRP-P is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Sarma, J. et al. (2002) Increased platelet binding to circulating monocytes in acute coronary syndromes. Circulation. 105: 2166 - 2171. 2. Bournazos, S. et al. (2008) Monocyte functional responsiveness after PSGL-1-mediated platelet adhesion is dependent on platelet activation status.Arterioscler Thromb Vasc Biol. 28: 1491-8. 3. Aasted, B. et al. (2007) Reactivity of monoclonal antibodies to human CD antigens with cells from mink.Vet Immunol Immunopathol. 119: 27-37. 4. Perdomo, J. et al. (2011) Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro.Blood. 117: 5975-86. 5. Harding, S.A. et al. (2004) Increased CD40 ligand and platelet-monocyte aggregates in patients with type 1 diabetes mellitus.Atherosclerosis. 176: 321-5. 6. Harding, S.A. et al. (2007) Clopidogrel reduces platelet-leucocyte aggregation, monocyte activation and RANTES secretion in type 2 diabetes mellitus.Heart. 92: 1335-7. 7. Eisbacher, M. et al. (2001) Inducible expression of the megakaryocyte-specific gene glycoprotein IX is mediated through an Ets binding site and involves upstream activation of extracellular signal-regulated kinase.Cell Growth Differ. 12: 435-45. 8. Vettore, S. et al. (2008) Novel point mutation in a leucine-rich repeat of the GPIbalpha chain of the platelet von Willebrand factor receptor, GPIb/IX/V, resulting in an inherited dominant form of Bernard-Soulier syndrome affecting two unrelated families: the N41H variant.Haematologica. 93: 1743-7. 9. Fox, S.C. et al. (2004) Quantitation of platelet aggregation and microaggregate formation in whole blood by flow cytometry.Platelets. 15: 85-93. 10. Din, J.N. et al. (2010) Effect of moderate walnut consumption on lipid profile, arterial stiffness and platelet activation in humans.Eur J Clin Nutr. 2011 Feb;65(2):234-9. 11. Din, J.N. et al. (2008) Dietary intervention with oil rich fish reduces platelet-monocyte aggregation in man.Atherosclerosis. 197: 290-6. 12. Schuberth, H.J. et al. (2007) Reactivity of cross-reacting monoclonal antibodies with canine leukocytes, platelets and erythrocytes.Vet Immunol Immunopathol. 119: 47-55.
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