|Calculated MW||57965 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||PHA activated human lymphocytes|
|Shelf Life||18 months from date of despatch.|
|Other Names||Ectonucleoside triphosphate diphosphohydrolase 1, NTPDase 1, 188.8.131.52, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, Ecto-apyrase, Lymphoid cell activation antigen, CD39, ENTPD1, CD39|
|Target/Specificity||Mouse anti-Human CD39, clone A1 recognizes the human CD39 cell surface antigen, a ~70-100 kDa molecule expressed on peripheral blood B cells, T cells and monocytes, and weakly expressed by granulocytes.CD39 has intrinsic ecto-ATPase activity (Wanget al.1996), and expression can be induced on T cells and increased on B cells, as a late activation antigen (Maliszewskiet al.1994).Mouse anti-Human CD39, clone A1 has been shown to block MHC independent target cell recognition by hapten-specific CTL (Scholzenet al.2009).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||Anti-Human CD39 Antibody, clone A1 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Aversa, G.G. et al. (1988) Detection of a late lymphocyte activation marker by A1, A new monoclonal antibody.Transpl. Proc. 20: 49 - 52 2. Waugh, J.A. et al. (1989) Staining of normal and rejecting kidney using the activation panel. In: Leucocyte Typing IV. White cell differentiation antigens. Edited by Knapp, W. et al.Oxford University Press. p485. 3. Aversa, G.G. and Hall, B.M. (1989) Activation panel antigen expression on PBL activated by PHA or in MLR. In: Leucocyte Typing IV. White cell differentiation antigens. Edited by Knapp, W. et al. Oxford University Press, p.498. 4. Aversa, G.G. et al. (1989) Use of monoclonal antibodies to study in vivoandin vitro activated lymphocytes.Transpl. Proc. 21: 349 - 350 5. Stein, H. et al. (1989) Activated Section report. In: Leucocyte Typing IV. White cell differentiation antigens. Edited by Knapp, W. et al. Oxford University Press, p.387. 6. Suranyi, M.G. et al. (1991) Lymphocyte adhesion molecules in T cell mediated lysis of kidney cells.Kidney International. 39: 312 - 319 7. Stockl, J. et al. (2001) Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1 restricted, hapten-specific CTL. J. Immunol. 167: 2724-2733. 8. Scholzen, A. et al. (2009) Plasmodium falciparum-mediated induction of human CD25Foxp3 CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta.PLoS Pathog. 5: e1000543. 9. Borsellino, G. et al. (2007) Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppressionBlood. 110:1225-32. 10. Mittag, D. et al. (2010) The effector T cell response to ryegrass pollen is counterregulated by simultaneous induction of regulatory T cells.J Immunol. 184: 4708-16. 11. Loeuillet, C. et al. (2008) In vitro whole-genome analysis identifies a susceptibility locus for HIV-1.PLoS Biol. 6: e32. 12. Rawstron, A.C. et al. (2010) Chronic lymphocytic leukaemia (CLL) and CLL-type monoclonal B-cell lymphocytosis (MBL) show differential expression of molecules involved in lymphoid tissue homing.Cytometry B Clin Cytom. 78 Suppl 1: S42-6. 13. Alam, M.S. et al. (2009) CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.J Infect Dis. 199: 494-504. 14. Moreno-Fernandez, M.E. et al. (2011) Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism.Blood. 117: 5372-80. 15. Guevara-Flores, A. et al. (2008) 5'-p-Fluorosulfonyl benzoyl adenosine inhibits an ecto-ATP-diphosphohydrolase in the tegument surface of Taenia crassiceps cysticerci.Mol Biochem Parasitol. 162: 123-33. 16. Glenn, J.R. et al. (2008) Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis.Platelets. 19: 59-69. 17. Häusler SF et al. (2014) Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion.Am J Transl Res. 6 (2): 129-39.
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