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Anti-Human CD88 Antibody, clone S5/1

Mouse Anti-Human Monoclonal Antibody

  • IHC - Anti-Human CD88 Antibody, clone S5/1  ABD12049
    Staining of paraffin embedded human lung with Mouse anti Human CD88
  • FC - Anti-Human CD88 Antibody, clone S5/1  ABD12049
    Staining of human peripheral blood granulocytes with Mouse anti Human CD88
  • FC - Anti-Human CD88 Antibody, clone S5/1  ABD12049
    Staining of human peripheral blood granulocytes with Mouse anti Human CD88:Endotoxin Low followed by Rabbit F(ab')2 anti Mouse IgG:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, FC, Func
Primary Accession P21730
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG2a
Clone Names S5/1
Calculated MW 39336 Da
Additional Information
Other Species Rb,Mustelid,B,Ferret,Mink
Purification Ig fraction prepared by ammonium sulphate precipitation
Immunogen C5aR - peptide: Met1 - Asn31.
Shelf Life 18 months from date of despatch.
Gene ID 728
Other Names C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor, C5a-R, C5aR, CD88, C5AR1, C5AR, C5R1
Target/Specificity Mouse anti-Human CD88 antibody, clone S5/1 recognizes the C5a receptor (C5aR) CD88, which is predominantly expressed on cells of the myeloid lineage. Clone S5/1 was raised against a synthetic peptide comprising the N-terminal extracellular domain of the C5aR (met1-Asn31) and has recently been shown to recognise the heptameric peptide (D15DKDTLD21).Clone S5/1 has been shown to inhibit the binding of C5a to its receptor.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Human CD88 Antibody, clone S5/1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Oppermann, M. et al. (1993) Probing the human receptor for C5a anaphylatoxin with site-directed antibodies.Identification of a potential ligand binding site on the NH2-terminal domain.
J Immunol. 151: 3785-94. 2. Oppermann, M. et al. (1995) Antibodies from the myeloid panel that react with the C5a receptor and antagonize C5a biological activity.
In: Schlossman, S.F. (ed.) Leucocyte Typing V. O.U.P. pp 955-956. 3. Werfel, T. et al. (1996) CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human skin.
J Immunol. 157: 1729-1735. 4. Oppermann, M & Gotze, O. et al. (1994) Plasma clearance of the human C5a anaphylatoxin by binding to leucocyte C5a receptors.
Immunology 82: 516-521. 5. Martel, C.J. & Aasted, B. (2009) Characterization of antibodies against ferret immunoglobulins, cytokines and CD markers.
Vet Immunol Immunopathol. 132:109-15. 6. Sopp, P. et al. (2007) Cross-reactivity of mAbs to human CD antigens with cells from cattle.
Vet Immunol Immunopathol. 119: 106-14. 7. Camous, L. et al. (2011) Complement alternative pathway acts as a positive feedback amplification of neutrophil activation.
Blood. 117: 1340-9. 8. Corrales, L. et al. (2012) Anaphylatoxin C5a Creates a Favorable Microenvironment for Lung Cancer Progression.
J Immunol. 189: 4674-83. 9. Hüttenrauch, F. et al. (2005) G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
J Biol Chem. 280: 37503-15. 10. Sumichika, H. et al. (2002) Identification of a potent and orally active non-peptide C5a receptor antagonist.
J Biol Chem. 277: 49403-7. 11. Thivierge, M. et al. (1999) Modulation of formyl peptide receptor expression by IL-10 in human monocytes and neutrophils.
J Immunol. 162: 3590-5. 12. Schreiber, A. et al. (2009) C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis.
J Am Soc Nephrol. 20: 289-98. 13. Eglite, S. et al. (2000) Requirements for C5a receptor-mediated IL-4 and IL-13 production and leukotriene C4 generation in human basophils.
J Immunol. 165: 2183-9. 14. Conroy, A. et al. (2009) C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.
PLoS One. 4: e4953. 15. Kraft, K. et al. (2001) Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization.
J Biol Chem. 276: 34408-18. 16. Fukuoka, Y. et al. (2008) Generation of anaphylatoxins by human beta-tryptase from C3, C4, and C5.
J Immunol. 180: 6307-16. 17. Aasted, B. and Viuff, B. (2007) Reactivity of monoclonal antibodies to human CD antigens with cells from mink.
Vet Immunol Immunopathol. 119: 27-37. 18. Huang, L. et al. (2005) Discovery of human antibodies against the C5aR target using phage display technology.
J Mol Recognit.18: 327-33.

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Cat# ABD12049
(40 western blots)
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