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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   Anti-Mouse Interleukin-10 Antibody, clone JES5-2A5 (RPE)   

Anti-Mouse Interleukin-10 Antibody, clone JES5-2A5

Rat Anti-Mouse Monoclonal Antibody

  • WB - Anti-Mouse Interleukin-10 Antibody, clone JES5-2A5  ABD12053
    Western blot analysis of mouse IL-10 recombinant protein probed with Rat anti Mouse Interleukin-10 followed by F(ab')2 Rabbit anti Rat IgG:HRP
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P18893
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG1
Clone Names JES5-2A5
Calculated MW 20641 Da
Additional Information
Other Species Ga
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Recombinant Mouse IL-10
Shelf Life 18 months from date of despatch.
Gene ID 16153
Other Names Interleukin-10, IL-10, Cytokine synthesis inhibitory factor, CSIF, Il10, Il-10
Target/Specificity Rat anti-Mouse Interleukin-10 antibody, clone JES5-2A5  recognizes mouse Cytokine synthesis inhibitory factor (CSIF), also known as interleukin-10 (IL-10). IL-10 is produced by Ly-1(CD5) expressing B cells (O'Garraet al.1992) and a subset of stimulated T cells (Assemanet al.1999).IL-10 has a wide range of biological properties, including the inhibition of macrophage and T helper cell mediated cytokine synthesis, and the suppression of the delayed hypersensitivity response.Rat anti-Mouse Interleukin-10 antibody, clone JES5-2A5 is reported to neutralize the activity of murine IL-10 (Weber-Nordtet al.1994).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse Interleukin-10 Antibody, clone JES5-2A5 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Abrams, J.S. et al. (1992) Strategies of anti-cytokine monoclonal antibody development: immunoassay of IL-10 and IL-5 in clinical samples.
Immunological Review 127: 5-24. 2. Sander, B. et al. (1993) Similar frequencies and kinetics of cytokine producing cells in murine peripheral blood and spleen. Cytokine detection by immunoassay and intracellular immunostaining
J. Immunol. Methods. 166: 201-14. 3. Guesdon, J.L. et al. (1979) The use of avidin-biotin interaction in immunoenzymatic techniques.
J. Histochem. Cytochem. 27: 1131-1139. 4. Nishigori, C. et al. (1998) Hind III liposomes suppress delayed-type hypersensitivity responses in vivo and induce epidermal IL-10 in vitro.
J. Immunol. 161:2684-2691. 5. Weber-Nordt, R. et al. (1994) Lipopolysaccharide-dependent induction of IL-10 receptor expression on murine fibroblasts.
J. Immunol. 153:3734-3744. 6. Rennick, D. et al. (1995) Cofactors are essential for stem cell factor-dependent growth and maturation of mast cell progenitors: comparative effects of interleukin-3 (IL-3), IL-4, IL-10, and fibroblasts.
Blood. 85: 57-65. 7. Sacco, S. et al. (1997) Protective effect of a single Interleukin-12 (IL-12) predose against the toxicity of subsequent chronic IL-12 in mice: Role of cytokines and glucocorticoids.
Blood. 90:4473-4479. 8. Biswas, S.K. et al. (2006) A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).
Blood. 107: 2112-22. 9. Gaupp, S. et al. (2008) Amelioration of experimental autoimmune encephalomyelitis in IL-4Ralpha-/- mice implicates compensatory up-regulation of Th2-type cytokines.
Am J Pathol. 173: 119-29. 10. Gonzalez-Juarrero, M. et al. (2013) Polar Lipids of Burkholderia pseudomallei Induce Different Host Immune Responses.
PLoS One. 8: e80368.

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Cat# ABD12053
(40 western blots)
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