|Application ||IHC-F, FC, IP|
|Calculated MW||88279 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Human T-cell leukaemia cells (T-CLL)|
|Shelf Life||18 months from date of despatch.|
|Other Names||Dipeptidyl peptidase 4, 220.127.116.11, ADABP, Adenosine deaminase complexing protein 2, ADCP-2, Dipeptidyl peptidase IV, DPP IV, T-cell activation antigen CD26, TP103, CD26, Dipeptidyl peptidase 4 membrane form, Dipeptidyl peptidase IV membrane form, Dipeptidyl peptidase 4 soluble form, Dipeptidyl peptidase IV soluble form, DPP4, ADCP2, CD26|
|Target/Specificity||Mouse anti-Human CD26 antibody, clone M-A261, recognizes human Dipeptidyl peptidase 4, also known as Adenosine deaminase complexing protein 2, CD26, TP103, ADABP or DPP IV. CD26 is a 766 amino acid ~110 kDa single pass type II transmembrane glycoprotein expressed by activated T cells, B cells and macrophages. A soluble form of CD26 can be derived by cleavage of the membrane bound form between residues 38-39 (Uniprot: 27487).CD26 acts as a functional receptor for the pathogenic Middle East respiratory syndrome coronavirus [MERS-CoV] (Rajet al.2014), a severe and frequently fatal disease in humans and marmosets sharing identical CD26 sequence at the site of interaction with the MERS-CoV spike protein (Luet al.2013,Wanget al.2013).Mouse anti-Human CD26 antibody, clone M-A261 has been used successfully for the immunohistochemical detection of CD26 on formalin fixed, paraffin embedded tissues and the demonstration of elevated CD26 expression in thyroid neoplasia (Kholováet al.2003). Mouse anti-Human CD26 antibody, clone M-A261 has also been used for the immunohistochemical detection of CD26 on cryostat sections using both immunoperoxidase and immunofluorescence staining in liver biopsies from NASH patients (Balabanet al.2007).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD26 Antibody, clone M-A261 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Berg, L.P. et al. (2002) Functional consequences of noncognate interactions between CD4+ memory T lymphocytes and the endothelium.J Immunol. 168 (7): 3227-34. 2. Post, S. et al. (2010) Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance.Cardiovasc Res. 85: 494-502. 3. Balaban, Y.H. et al. (2007) Dipeptidyl peptidase IV (DDP IV) in NASH patients.Ann Hepatol. 6: 242-50. 4. Krijnen, P.A. et al. (2012) Loss of DPP4 activity is related to a prothrombogenic status of endothelial cells: implications for the coronary microvasculature of myocardial infarction patients.Basic Res Cardiol. 107: 233. 5. Kholová, I. et al. (2003) Immunohistochemical detection of dipeptidyl peptidase IV (CD 26) in thyroid neoplasia using biotinylated tyramine amplification. Neoplasma. 50: 159-64. 6. Lutz, M.S. and Burk, R.D. (2006) Primary cilium formation requires von hippel-lindau gene function in renal-derived cells.Cancer Res. 66: 6903-7. 7. James, M.J.
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