|Application ||FC, IP|
|Calculated MW||25170 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell-specific surface glycoprotein CD28, CD28, Cd28|
|Target/Specificity||Mouse anti-Rat CD28 antibody, clone JJ319 recognizes the rat cell surface antigen CD28, a type I transmembrane glycoprotein, expressed by the majority of T lymphocytes and a subset of NK cells.CD28 is an essential costimulatory receptor for T cell activation and a modulator of T-cell cytokine production. Ligands of CD28 include CD80 (B7-1), CD86 (B7-2) and P13-kinase.>Mouse anti-Rat CD28 antibody, clone JJ319 has been identified as a highly effective co-stimulator of T cell proliferation and IL-2 secretion by resting T cells (Tackeet al.1995).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||CD28 Antibody, clone JJ319 (Monoclonal Antibody) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Tacke, M. et al. (1995) Cellular distribution and costimulatory function of rat CD28. Regulated expression during thymocyte maturation and induction of cyclosporin A sensitivity of costimulated T cell responses by phorbol ester.J. Immunol. 154: 5121-7. 2. Tacke, M. et al. (1997) CD28-mediated induction of proliferation in resting T cells in vitro and in vivo without engagement of the T cell receptor: evidence for functionally distinct forms of CD28.Eur. J. Immunol. 27:239-247.
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