|Calculated MW||109343 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G.|
|Immunogen||IL-3 dependent mast cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Mast/stem cell growth factor receptor Kit, SCFR, 188.8.131.52, Proto-oncogene c-Kit, Tyrosine-protein kinase Kit, CD117, Kit, Sl|
|Target/Specificity||Rat anti-Mouse CD117 antibody, clone 2B8 recognizes mouse CD117, a 150kDa cell surface molecule that is otherwise known as the Kit, or c-kit, receptor.Rat anti-Mouse CD117 antibody, clone 2B8 recognizes an epitope within the extracellular region of CD117. In mice, CD117 is predominantly expressed on multipotent haematopoietic stem cells from the adult bone marrow and foetal liver.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD117 Antibody, clone 2B8 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Ikuta, K. and Weissman, I.L. (1992) Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.Proc. Nat. Acad. Sci. USA 89: 1502-1506. 2. Fleming, W.H. et al. (1993) Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo.Proc. Natl. Acad. Sci. USA 90: 3760-3764. 3. Rico-Vargas, S.A. et al. (1994) c-kit expression by B cell precursors in mouse bone marrow. Stimulation of B cell genesis by in vivo treatment with anti-c-kit antibodyJ. Immunol. 152: 2845-2852. 4. Manova, K. et al. (1992) c-kit receptor and ligand expression in postnatal development of the mouse cerebellum suggests a function for c-kit in inhibitory interneurons.J. Neurosci. 12: 4663-4676. 5. Maeda, H. et al. (1992) Requirement of c-kit for development of intestinal pacemaker system.Development 116: 369-375. 6. Takagi, M. et al. (1992) Stimulation of mouse connective tissue-type mast cells by hemopoietic stem cell factor, a ligand for the c-kit receptor.J. Immunol. 148: 3446-3453. 7. de Vrics, P. et al. (1992) Thymus reconstitution by c-kit expressing hematopoietic stem cells purified from adult mouse bone marrow.J. Exp. Med. 176: 1503-1509. 8. Yoshinaga, K. et al. (1991) Role of c-kit in mouse spermatogenesis: identification of spermatogonia as a specific site of c-kit expression and function.Development 113: 689-699.
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