|Application ||FC, IP, Func|
|Calculated MW||128328 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Immunogen||Whole BW5147 cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, Lymphocyte antigen 15, Ly-15, CD11a, Itgal, Lfa-1, Ly-15|
|Target/Specificity||Rat anti-Mouse CD11a antibody, clone I21/7 recognizes murine CD11a, a ~170-180kDa type I membrane glycoprotein, also known as the integrin alpha L subunit. CD11a is a member of the intergrin family of adhesion molecules. CD11a is expressed on all leucocytes and associates with CD18 to form a heterodimer at the cell surface. The CD11a/CD18 heterodimer binds to intercellular adhesion molecules (ICAM); ICAM1, ICAM-2 and ICAM-3 and is involved in cell-cell adhesion processes.Rat anti-Mouse CD11a antibody, clone I21/7 is reported to block the cytolytic activity of cytotoxic T cell lines (Trowbridge and Omary 1981).|
|Preservative & Stabilisers||Preservative Free|
|Storage||Store at -20℃ only.|
|Precautions||Anti-Mouse CD11a Antibody, clone I21/7 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Trowbridge, I.S. & Omary, M.B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.J Exp Med. 154 (5): 1517-24. 2. Champe, M. et al. (1995) Monoclonal antibodies that block the activity of leukocyte function-associated antigen 1 recognize three discrete epitopes in the inserted domain of CD11a.J Biol Chem. 270 (3): 1388-94. 3. Campbell, S.B. et al. (2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells.J Immunol. 167 (10): 5610-9. 4. Talento, A. et al. (1993) A single administration of LFA-1 antibody confers prolonged allograft survival.Transplantation. 55 (2): 418-22. 5. Barrett, T.B. et al. (1991) CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.J Immunol. 146 (6): 1722-9. 6. Kleinschnitz, C. et al. (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.Blood. 121: 679-691 7. Falanga, P.B. & Butcher, E.C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model.Eur J Immunol. 21 (9): 2259-63.1. Springer, T.A. et al. (1982) LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.Immunol Rev. 68: 171-95.
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