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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Mouse CD11a Antibody, clone I21/7 (RPE)   

Anti-Mouse CD11a Antibody, clone I21/7

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse CD11a Antibody, clone I21/7  ABD12066
    Staining of mouse spleen cells with Rat anti Mouse CD11a
  • FC - Anti-Mouse CD11a Antibody, clone I21/7  ABD12066
    Staining of mouse spleen cells with Rat anti Mouse CD11a:FITC
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IP, Func
Primary Accession P24063
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names I21/7
Calculated MW 128328 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Immunogen Whole BW5147 cells.
Shelf Life 18 months from date of despatch.
Other Names Integrin alpha-L, CD11 antigen-like family member A, Leukocyte adhesion glycoprotein LFA-1 alpha chain, LFA-1A, Leukocyte function-associated molecule 1 alpha chain, Lymphocyte antigen 15, Ly-15, CD11a, Itgal, Lfa-1, Ly-15
Target/Specificity Rat anti-Mouse CD11a antibody, clone I21/7 recognizes murine CD11a, a ~170-180kDa type I membrane glycoprotein, also known as the integrin alpha L subunit. CD11a is a member of the intergrin family of adhesion molecules. CD11a is expressed on all leucocytes and associates with CD18 to form a heterodimer at the cell surface. The CD11a/CD18 heterodimer binds to intercellular adhesion molecules (ICAM); ICAM1, ICAM-2 and ICAM-3 and is involved in cell-cell adhesion processes.Rat anti-Mouse CD11a antibody, clone I21/7 is reported to block the cytolytic activity of cytotoxic T cell lines (Trowbridge and Omary 1981).
Preservative & Stabilisers Preservative Free
Storage Store at -20℃ only.
PrecautionsAnti-Mouse CD11a Antibody, clone I21/7 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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1. Trowbridge, I.S. & Omary, M.B. (1981) Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.
J Exp Med. 154 (5): 1517-24. 2. Champe, M. et al. (1995) Monoclonal antibodies that block the activity of leukocyte function-associated antigen 1 recognize three discrete epitopes in the inserted domain of CD11a.
J Biol Chem. 270 (3): 1388-94. 3. Campbell, S.B. et al. (2001) CD4 ligation promotes the IL-4-independent development of IL-4-producing clones from naive CD4(+) T cells.
J Immunol. 167 (10): 5610-9. 4. Talento, A. et al. (1993) A single administration of LFA-1 antibody confers prolonged allograft survival.
Transplantation. 55 (2): 418-22. 5. Barrett, T.B. et al. (1991) CD40 signaling activates CD11a/CD18 (LFA-1)-mediated adhesion in B cells.
J Immunol. 146 (6): 1722-9. 6. Kleinschnitz, C. et al. (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature.
Blood. 121: 679-691 7. Falanga, P.B. & Butcher, E.C. (1991) Late treatment with anti-LFA-1 (CD11a) antibody prevents cerebral malaria in a mouse model.
Eur J Immunol. 21 (9): 2259-63.1. Springer, T.A. et al. (1982) LFA-1 and Lyt-2,3, molecules associated with T lymphocyte-mediated killing; and Mac-1, an LFA-1 homologue associated with complement receptor function.
Immunol Rev. 68: 171-95.

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Cat# ABD12066
(40 western blots)
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