|Calculated MW||34666 Da|
|Purification||Purified IgG prepared by ion exchange chromatography.|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-lymphocyte activation antigen CD86, Activation B7-2 antigen, Early T-cell costimulatory molecule 1, ETC-1, CD86, Cd86|
|Target/Specificity||Rat anti-Mouse CD86 antibody, clone RMMP-2 recognizes the murine CD86 cell surface antigen, also known as Activation B7-2 antigen or Early T-cell costimulatory molecule 1. CD86 is a 286 amino acid ~35 kDa single pass type type I transmembrane glycoprotein acting as a receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production.CD86 along with CD80 acts as a cell attachment receptor for group B adenoviruses (Shortet al.2006).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||Anti-Mouse CD86 Antibody, clone RMMP-2 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Tang, C. et al. (2001) Th type 1-stimulating activity of lung macrophages inhibits Th2-mediated allergic airway inflammation by an IFN-gamma-dependent mechanism.J Immunol. 166 (3): 1471-81. 2. Cohen-Sfady, M. et al. (2005) Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway.J Immunol. 175 (6): 3594-602. 3. Mercier, S. et al. (2002) Distinct roles of adenovirus vector-transduced dendritic cells, myoblasts, and endothelial cells in mediating an immune response against a transgene product.J Virol. 76 (6): 2899-911. 4. Greicius, G. et al. (2004) Microvilli structures on B lymphocytes: inducible functional domains?Int Immunol. 16: 353-64. 5. Sireci, G. et al. (2009) A continuous infusion of a minor histocompatibility antigen-immunodominant peptide induces a delay of male skin graft rejection.Immunobiology. 214: 703-11. 6. Vliegen, I. et al. (2004) Murine cytomegalovirus infection directs macrophage differentiation into a pro-inflammatory immune phenotype: implications for atherogenesisMicrobes Infect. 6: 1056-62. 7. Wang, R. et al. (2008) GAD-IgG-inducing CD4+Foxp3+Treg cells suppressing diabetes are involved in the increasing ratio of CD80+:CD86+ CELLS in NOD mice.Arch Med Res. 39 (3): 299-305. 8. Mohan, J. et al. (2005) Skin-derived dendritic cells acquire and degrade the scrapie agent following in vitroexposure.Immunology. 116: 122-33.
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