|Application ||IHC-F, FC|
|Calculated MW||51297 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.|
|Shelf Life||18 months from date of despatch.|
|Other Names||T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, CD4, Cd4|
|Target/Specificity||Rat anti-Mouse CD4 antibody, clone YTS191.1 recognizes the murine CD4 cell surface antigen, expressed by a subset of T lymphocytes.Rat anti-Mouse CD4 antibody, clone YTS191.1 exhibits depleting activity when used in vivo(Bemelmanet al.1998).|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD4 Antibody, clone YTS191.1 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Cobbold, S.P. et al. (1990) The induction of skin graft tolerance in MHC-mismatched or primed recipients: primed T cells can be tolerized in the periphery with CD4 and CD8 antibodies.Eur. J. Immunol. 20: 2747-2755. 2. Bemelman, F. et al. (1998) Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.J. Immunol. 160: 2645-2648. 3. Higgins, L. M. et al. (1999) Regulation of T cell activation in vitroandin vivo by targeting the OX40-OX40 Ligand Interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand - IgG fusion protein. J. Immunol. 162: 486 - 493. 4. Croxford, J.L. et al. (2001) Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: a comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system.J Immunol. 166: 4124-30. 5. Eller, K. et al. (2011) IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression.J Immunol. 186: 83-91. 6. Gaupp, S. et al. (2008) Amelioration of experimental autoimmune encephalomyelitis in IL-4Ralpha-/- mice implicates compensatory up-regulation of Th2-type cytokines.Am J Pathol. 173: 119-29. 7. Grimm, M.et al. (2010) Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases.BMC Cancer. 10: 82. 8. Jégou, J.F. et al. (2007) C3d Binding to the Myelin Oligodendrocyte Glycoprotein Results in an Exacerbated Experimental Autoimmune EncephalomyelitisJ Immunol. 178: 3323-31. 9. Huber, J.M. et al. (2009) The proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.Am J Physiol Renal Physiol. 297: F451-60. 10. Wolf, D. et al. (2005) CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice.J Am Soc Nephrol. 16: 1360-70. 11. Abdulreda, M.H. et al. (2011) High-resolution, noninvasive longitudinal live imaging of immune responses.Proc Natl Acad Sci U S A. 108: 12863-8. 12. Nakashima, H. et al. (2011) A Novel Combination Immunotherapy for Cancer by IL-13Ra2-Targeted DNA Vaccine and Immunotoxin in Murine Tumor Models.J Immunol. 187: 4935-46. 13. Scotland, R.S. et al. (2011) Sex-differences in resident immune cell phenotype underlies more efficient acute inflammatory responses in female mice.Blood. 118: 5918-27. 14. Zitt, E. et al. (2011) The selective mineralocorticoid receptor antagonist eplerenone is protective in mild anti-GBM glomeru-lonephritis.Int J Clin Exp Pathol. 4:606-15.
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