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>   home   >   Products   >   Primary Antibodies   >   Stem Cells   >   Anti-Mouse CD4 Antibody, clone YTS191.1    

Anti-Mouse CD4 Antibody, clone YTS191.1

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse CD4 Antibody, clone YTS191.1  ABD12112
    Staining of mouse spleen cells with Rat anti Mouse CD4: APC
  • FC - Anti-Mouse CD4 Antibody, clone YTS191.1  ABD12112
    Staining of mouse spleen with Rat anti Mouse CD4
  • IF - Anti-Mouse CD4 Antibody, clone YTS191.1  ABD12112
    Published customer image:Rat anti Mouse CD4 antibody, clone YTS191.1 used for the detection of CD4 positive lymphocytes in mouse liver metastases by immunohustochemistry and immunofluorescence on acetone trated cryosections.Image caption:(a) Immunohistochemistry and (b) immunofluorescence double staining: Representative image of CD4 /CD8 expression and Foxp3 /CD4 expression in liver metastases on day 10 (n = 7) compared to increased CD4 /CD8 expression and Foxp3 /CD4 expression on day 20. Immunohistochemistry: Nova red brick red color, Vector Blue blue color. Haemalaun blue color-nuclear counterstaining. Asterisk with indication lines show metastases next to normal tissue (×100 and ×400). Immunofluorescence: FITC green fluorescein isothiocyanate, Cy3 red and DAPI 4',6-diamidino-2-phenylindole blue - nuclear counterstaining (×250).From: Grimm M, Gasser M, Bueter M, Strehl J, Wang J, Nichiporuk E, Meyer D, Germer CT, Waaga-Gasser AM, Thalheimer A. Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases. BMC Cancer. 2010 Mar 7;10:82.
  • FC - Anti-Mouse CD4 Antibody, clone YTS191.1  ABD12112
    Staining of mouse spleen cells with Rat anti Mouse CD4:RPE
  • FC - Anti-Mouse CD4 Antibody, clone YTS191.1  ABD12112
    Staining of mouse spleen with Rat anti Mouse CD4: Low Endotoxin
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P06332
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2b
Clone Names YTS191.1
Calculated MW 51297 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant.
Shelf Life 18 months from date of despatch.
Gene ID 12504
Other Names T-cell surface glycoprotein CD4, T-cell differentiation antigen L3T4, T-cell surface antigen T4/Leu-3, CD4, Cd4
Target/Specificity Rat anti-Mouse CD4 antibody, clone YTS191.1 recognizes the murine CD4 cell surface antigen, expressed by a subset of T lymphocytes.Rat anti-Mouse CD4 antibody, clone YTS191.1 exhibits depleting activity when used in vivo(Bemelmanet al.1998).
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse CD4 Antibody, clone YTS191.1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Cobbold, S.P. et al. (1990) The induction of skin graft tolerance in MHC-mismatched or primed recipients: primed T cells can be tolerized in the periphery with CD4 and CD8 antibodies.
Eur. J. Immunol. 20: 2747-2755. 2. Bemelman, F. et al. (1998) Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.
J. Immunol. 160: 2645-2648. 3. Higgins, L. M. et al. (1999) Regulation of T cell activation in vitroandin vivo by targeting the OX40-OX40 Ligand Interaction: Amelioration of ongoing inflammatory bowel disease with an OX40-IgG fusion protein, but not with an OX40 ligand - IgG fusion protein.
J. Immunol. 162: 486 - 493. 4. Croxford, J.L. et al. (2001) Different therapeutic outcomes in experimental allergic encephalomyelitis dependent upon the mode of delivery of IL-10: a comparison of the effects of protein, adenoviral or retroviral IL-10 delivery into the central nervous system.
J Immunol. 166: 4124-30. 5. Eller, K. et al. (2011) IL-9 production by regulatory T cells recruits mast cells that are essential for regulatory T cell-induced immune suppression.
J Immunol. 186: 83-91. 6. Gaupp, S. et al. (2008) Amelioration of experimental autoimmune encephalomyelitis in IL-4Ralpha-/- mice implicates compensatory up-regulation of Th2-type cytokines.
Am J Pathol. 173: 119-29. 7. Grimm, al. (2010) Evaluation of immunological escape mechanisms in a mouse model of colorectal liver metastases.
BMC Cancer. 10: 82. 8. Jégou, J.F. et al. (2007) C3d Binding to the Myelin Oligodendrocyte Glycoprotein Results in an Exacerbated Experimental Autoimmune Encephalomyelitis
J Immunol. 178: 3323-31. 9. Huber, J.M. et al. (2009) The proteasome inhibitor bortezomib aggravates renal ischemia-reperfusion injury.
Am J Physiol Renal Physiol. 297: F451-60. 10. Wolf, D. et al. (2005) CD4+CD25+ regulatory T cells inhibit experimental anti-glomerular basement membrane glomerulonephritis in mice.
J Am Soc Nephrol. 16: 1360-70. 11. Abdulreda, M.H. et al. (2011) High-resolution, noninvasive longitudinal live imaging of immune responses.
Proc Natl Acad Sci U S A. 108: 12863-8. 12. Nakashima, H. et al. (2011) A Novel Combination Immunotherapy for Cancer by IL-13Ra2-Targeted DNA Vaccine and Immunotoxin in Murine Tumor Models.
J Immunol. 187: 4935-46. 13. Scotland, R.S. et al. (2011) Sex-differences in resident immune cell phenotype underlies more efficient acute inflammatory responses in female mice.
Blood. 118: 5918-27. 14. Zitt, E. et al. (2011) The selective mineralocorticoid receptor antagonist eplerenone is protective in mild anti-GBM glomeru-lonephritis.
Int J Clin Exp Pathol. 4:606-15.

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Cat# ABD12112
(40 western blots)
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