|Application ||IHC-F, FC|
|Calculated MW||27456 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Shelf Life||12 months from date of reconstitution.|
|Other Names||T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein Lyt-2, CD8a, Cd8a, Lyt-2, Lyt2|
|Target/Specificity||Rat anti-Mouse CD8 antibody, clone YTS169.4 recognizes the murine CD8 cell surface antigen, expressed by a subset of T lymphocytes.Rat anti-Mouse CD8 antibody, clone YTS169.4 exhibits depleting activity when used in vivo.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Mouse CD8 Antibody, clone YTS169.4 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Cobbold, S.P. et al. (1990) The induction of skin graft tolerance in MHC-mismatched or primed recipients: primed T cells can be tolerized in the periphery with CD4 and CD8 antibodies.Eur. J. Immunol. 20: 2747. 2. Bemelman, F. et al. (1998) Bone marrow transplantation induces either clonal deletion or infectious tolerance depending on the dose.J. Immunol. 160: 2645-2648. 3. Cobbold, S.P. et al. (1984) Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo.Nature 312: 548-551. 4. Wise, M.P. et al. (1998) Cutting Edge; Linked suppression of skin graft rejection can operate through indirect recognition.J. Immunol. 161: 5813-5816. 5. Higgins, L. M. et al. (1999) Regulation of T-cell activation in vitroandin vivo by targeting the OX40 -OX40 Ligand Interaction: Amelioration of ongoing inflammatory bowel disease with an OX40 - IgG fusion protein, but not with an OX40 ligand - IgG fusion protein. J. immunol. 162: 486 - 493. 6. Scotland, R.S. et al. (2011) Sex-differences in resident immune cell phenotype underlies more efficient acute inflammatory responses in female mice.Blood. 118: 5918-27.
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